Results 71 to 80 of about 93,317 (199)

Human Intestinal Enteroids for the Study of Bacterial Adherence, Invasion, and Translocation. [PDF]

Curr Protoc Microbiol, 2018
AbstractAdherence, invasion, and translocation to and through the intestinal epithelium are important drivers of disease for many enteric bacteria. However, most work has been limited to transformed intestinal cell lines or murine models that often do not faithfully recapitulate key elements associated with human disease.
Poole NM, Rajan A, Maresso AW.
europepmc   +4 more sources

Polarized Distribution of Lipid Droplets with Long Acyl Chains and Unsaturation are Hallmarks of Human Intestinal Enteroid Differentiation. [PDF]

Anal Chem
Johansson PK, Liu Y, Klett KC, Heilshorn SC, Enejder A.   +4 more
europepmc   +3 more sources

Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. [PDF]

, 2019
Adult intestinal epithelial stem cells are a promising resource for treatment of intestinal epithelial disorders that cause intestinal failure and for intestinal tissue engineering.
Cho, Yonghoon, Dunn, James CY, Hong, Sung Noh, Khalil, Hassan A, Lewis, Michael S, Martin, Martin G, Rouch, Joshua D, Scott, Andrew, Stelzner, Matthias G, Wang, Jiafang   +9 more
core   +2 more sources

Engineered Matrices Enable the Culture of Human Patient‐Derived Intestinal Organoids

Advanced Science, 2021
Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models.
Daniel R. Hunt, Katarina C. Klett, Shamik Mascharak, Huiyuan Wang, Diana Gong, Junzhe Lou, Xingnan Li, Pamela C. Cai, Riley A. Suhar, Julia Y. Co, Bauer L. LeSavage, Abbygail A. Foster, Yuan Guan, Manuel R. Amieva, Gary Peltz, Yan Xia, Calvin J. Kuo, Sarah C. Heilshorn   +17 more
doaj   +1 more source

Human enteroids: Preclinical models of non-inflammatory diarrhea [PDF]

, 2013
Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing drug therapy.
Broughman, J.R. (James), Donowitz, M. (Mark), Estes, M. (Mary), Ettayebi, K. (Khalil), Foulke-Abel, J. (Jennifer), Hyser, J.M. (Joseph), In, J. (Julie), Jonge, H.R. (Hugo) de, Kovbasnjuk, O. (Olga), Middendorp, S., Zachos, N.C. (Nicholas C.), Zeng, X.-L. (Xi-Lei)   +11 more
core   +1 more source

WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals

Biology Open, 2017
Recent years have seen significant developments in the ability to continuously propagate organoids derived from intestinal crypts. These advancements have been applied to mouse and human samples providing models for gastrointestinal tissue development ...
Robin H. Powell, Michael S. Behnke
doaj   +1 more source

Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]

, 2013
Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D, Falk, Gary W, Hartman, Kira G, Lynch, John P, Martín, Martín G, Rustgi, Anil K, Yu, Jian   +6 more
core   +2 more sources

Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium.

PLoS ONE, 2020
Enteroids are cultured primary intestinal epithelial cells that recapitulate epithelial lineage development allowing for a more complex and physiologically relevant model for scientific study.
Sarah C Pearce, Gregory J Weber, Dana M van Sambeek, Jason W Soares, Kenneth Racicot, David T Breault   +5 more
doaj   +1 more source

Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages [PDF]

, 2018
Recently, three‐dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic ...
Aoki-Yoshida, Barker, Farin, Finkbeiner, Forbester, Foureau, Gregorieff, Grootjans, Kaser, Komiya, McDole, Menendez, Patel, Peeters, Pelaseyed, Peterson, Pin, Pinto, Rodriguez-Pineiro, Salzman, Sato, Schweinlin, Specian, Uhlen, Wilson, Yin, Yin, Zhang, Zhang   +28 more
core   +5 more sources

A Standardized Antiviral Pipeline for Human Norovirus in Human Intestinal Enteroids Demonstrates No Antiviral Activity of Nitazoxanide

bioRxiv, 2023
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis. In immunocompetent hosts, symptoms usually resolve within three days; however, in immunocompromised persons, HuNoV infection can become persistent, debilitating, and sometimes ...
M. A. Lewis, Nicolas W. Cortes-Penfield, K. Ettayebi, K. Patil, Gurpreet Kaur, F. Neill, R. Atmar, S. Ramani, M. Estes   +8 more
semanticscholar   +1 more source