Results 81 to 90 of about 93,317 (199)

HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome

Vaccines, 2023
Norovirus infection is the leading cause of foodborne gastroenteritis worldwide, causing more than 200,000 deaths each year. As a result of a lack of reproducible and robust in vitro culture systems and suitable animal models for human norovirus (HuNoV ...
Nini Chen, Peiyu Chen, Yanhe Zhou, Sidong Chen, Sitang Gong, Ming Fu, Lanlan Geng   +6 more
doaj   +1 more source

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions [PDF]

, 2017
Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Begum, Yasmin Ara, Ciorba, Matthew A, Fleckenstein, James M, Hultgren, Scott J, Kuhlman, F. Matthew, Qadri, Firdausi, Rashu, Rasheduzzaman, Sheikh, Alaullah   +7 more
core   +3 more sources

Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2021
This study showed that polarized enteroid models in which there is no basolateral Wnt3a, are differentiated, regardless of the Wnt3a status of the apical media. The study supports the concept that in the human intestine villus differentiation is not an all or none phenomenon, demonstrating that at different days after lack of basolateral Wnt exposure,
Jianyi, Yin, Laxmi, Sunuwar, Magdalena, Kasendra, Huimin, Yu, Chung-Ming, Tse, C Conover, Talbot, Tatiana, Boronina, Robert, Cole, Katia, Karalis, Mark, Donowitz   +9 more
openaire   +3 more sources

Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. [PDF]

, 2020
The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high-throughput screen.
Alli, Claudia, Bhat, Kruttika, Cheng, Fei, Duhachek-Muggy, Sara, Eghbali, Mansoureh, He, Ling, Medina, Paul, Muthukrishnan, Sree Deepthi, Pajonk, Frank, Ruffenach, Gregoire, Saki, Mohammad, Vlashi, Erina   +11 more
core   +1 more source

Tissue Responses to Shiga Toxin in Human Intestinal OrganoidsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Shiga toxin (Stx)-producing Escherichia coli (eg, O157:H7) infection produces bloody diarrhea, while Stx inhibits protein synthesis and causes the life-threatening systemic complication of hemolytic uremic syndrome.
Suman Pradhan, Sayali S. Karve, Alison A. Weiss, Jennifer Hawkins, Holly M. Poling, Michael A. Helmrath, James M. Wells, Heather A. McCauley   +7 more
doaj   +1 more source

The zinc finger transcription factor PLAGL2 enhances stem cell fate and activates expression of ASCL2 in intestinal epithelial cells [PDF]

, 2010
O encaminhamento de textos originais para submissão seguem algumas orientações básicas, levando em conta, inicialmente, que devem ser inéditos e que serão submetidos à aprovação de avaliadores especialistas nos temas tratados.
Strubberg, Ashlee M, Veronese Paniagua, Daniel A, Zhao, Tingting, Dublin, Leeran, Pritchard, Thomas, Bayguinov, Peter O, Fitzpatrick, James A.J., Madison, Blair B   +7 more
core   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Let-7 represses carcinogenesis and a stem cell phenotype in the intestine via regulation of Hmga2 [PDF]

, 2015
Let-7 miRNAs comprise one of the largest and most highly expressed family of miRNAs among vertebrates, and is critical for promoting differentiation, regulating metabolism, inhibiting cellular proliferation, and repressing carcinogenesis in a variety of ...
Castells, Antoni, Cuatrecasas, Miriam, Jeganathan, Arjun N, Madison, Blair B, Mizuno, Rei, Rustgi, Anil K, Winslow, Monte M   +6 more
core   +4 more sources

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source