Results 181 to 190 of about 8,857,203 (292)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span. [PDF]

open access: yesMol Biol Evol, 2021
Farré X   +9 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Human rights vs. human life

open access: yes, 2018
In 1977 an incident occurred in a tiny fisherman village located in the south-eastern corner of Italy, which resonated in both Washington and Moscow. That kind of linkages in history, combining the micro and macro levels of analysis simultaneously, is what inspires me the most as a historian and what makes me feel so much at home at EUR’s history ...
openaire   +1 more source

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