Results 81 to 90 of about 8,915,710 (312)
From Biosemiotics to Semiotics [PDF]
, 2002 Biosemiotics and Semiotics have similarities and differences. Both deal with signal and meaning. One difference is that Biosemiotics covers a domain (life) that is less complex that the one addressed by Semiotics (human).
Menant, Christophe
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Human Life as a Basic Good: A Dialectical Critique
Ideas y Valores, 2016 In this article I argue that the fundamental axiological claim of the New Natural Law Theory, according to which human life has an intrinsically valuable, cannot be defended within the framework assumed by the New Natural Law Theory itself, and further ...
Javier Echeñique Sosa
doaj
The Value of Human Life a Divine Right in the Judicial European Space Pros and Cons of Euthanasia
EIRP Proceedings, 2020 Respect fullness for every person’s right to life and human dignity can be found in most of the great religions and ideologies throughout the world.
Ana Alina Ionescu Dumitrache +1 more
doaj
Turing Test, Chinese Room Argument, Symbol Grounding Problem. Meanings in Artificial Agents [PDF]
, 2012 The Turing Test (TT), the Chinese Room Argument (CRA), and the Symbol Grounding Problem (SGP) are about the question “can machines think?”. We propose to look at that question through the capability for Artificial Agents (AAs) to generate meaningful ...
Menant, Mr Christophe
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A Metaphysics of Human Life. Towards a New Reading of Spinoza’s Philosophy
Journal of Spinoza Studies, 2022 Ursula Renz
doaj +1 more source