Results 121 to 130 of about 13,528,447 (353)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Fields of Conflict: Public Attitudes and Economic Impacts of Human–Wildlife Conflict on Rural Livelihood in District Lakki Marwat, Pakistan

open access: yesDiversity
Human–wildlife conflict poses significant ecological and socio-economic challenges, particularly in rural communities where agriculture and livestock rearing form the backbone of livelihoods.
Tauheed Ullah Khan   +4 more
doaj   +1 more source

Trends in Worker Displacement Penalties in Japan: 1991-2005 [PDF]

open access: yes
We examine the period from 1991 to 2005 to document the effects of a changing Japanese labor market on trends in the cost of job change. During this period, job change penalties and the extent to which they were age-related grew.
Michael Bognanno, Ryo Kambayashi
core  

TINJAUAN YURIDIS NORMATIF PEMENUHAN HAK KORBAN PELANGGARAN HAM BERAT DI INDONESIA [PDF]

open access: yes, 2010
Violations of serious human rights is a severe crime that resulted in extraordinary losses in material and the victim imateriil. Victims who have suffered various sufferings in this case often does not get the protection and fulfillment of the rights ...
Fatimah, Sheila
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The Cost of War in Human Dimension: The Case of Lanao del Sur [PDF]

open access: yes
The conflict in Muslim Mindanao, particularly in Lanao del Sur, is complex, deeply rooted, and multifaceted. Through its long history, the conflict has brought tremendous economic losses but it is in terms of the human dimension that the strongest impact
Busran-Lao, Yasmin
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Special Issue: Honey Bee Viruses

open access: yesViruses, 2015
Pollination of flowering plants is an important ecosystem service provided by wild insect pollinators and managed honey bees. Hence, losses and declines of pollinating insect species threaten human food security and are of major concern not only for ...
Sebastian Gisder, Elke Genersch
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

HEALTH COSTS AND EXTERNALITIES OF PESTICIDE USE IN LOCUST AND GRASSHOPPER CONTROL IN THE SAHEL [PDF]

open access: yes
To evaluate the economic cost of classical chemical control of locusts, externalities of chemical pesticides in the Sahel are estimated through a farmer survey.
De Groote, Hugo, Houndekon, Victorin A.
core   +1 more source

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