Results 81 to 90 of about 13,528,447 (353)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Impact of in-hospital birth weight loss on short and medium term breastfeeding outcomes

International Breastfeeding Journal, 2018
Background The definition for lower limit of safe birthweight loss among exclusively breastfed neonates is arbitrary. Despite this, in cases of great in-hospital weight loss, breastfeeding adequacy is immediately questioned.
Sergio Verd, Diego de Sotto, Consuelo Fernández, Antonio Gutiérrez   +3 more
doaj   +1 more source

The Discounted Money Value of Human Life Losses Associated With COVID-19 in Mauritius

Frontiers in Public Health, 2020
Background: Mauritius along with other 12 countries in the African Region was identified at the early start of the COVID-19 pandemic as being at high risk due to high volume of international travel, high prevalence of non-communicable diseases and co ...
Laurent Musango, Ajoy Nundoochan, Joses Muthuri Kirigia   +2 more
doaj   +1 more source

Mouse models for human hair loss disorders [PDF]

Journal of Anatomy, 2003
AbstractThe outer surface of the hand, limb and body is covered by the epidermis, which is elaborated into a number of specialized appendages, evolved not only to protect and reinforce the skin but also for social signalling. The most prominent of these appendages is the hair follicle.
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Quantifying evaporation losses in the river-lake continuum in arid regions basins using isotope data

Ecological Indicators
Understanding surface water evaporation losses is essential for quantifying water balance and optimizing resource management in arid inland basins. Arid inland regions face severe water scarcity driven by high evaporation and intensive human regulation ...
Xiaoyu Qi, Zhigang Sun, Guofeng Zhu, Rui Li, Yinying Jiao, Zhijie Zheng, Wenmin Li, Yani Gun, Jiangwei Yang, Ziwen Liu   +9 more
doaj   +1 more source

Impact of One-Health framework on vaccination cost-effectiveness: A case study of rabies in Ethiopia

One Health, 2019
Livestock losses due to rabies and health and the corresponding benefits of controlling the disease are not often considered when the cost-effectiveness of rabies control is evaluated.
Tariku Jibat Beyene, Meagan C. Fitzpatrick, Alison P. Galvani, Monique C.M. Mourits, Crawford W. Revie, Natalia Cernicchiaro, Michael W. Sanderson, Henk Hogeveen   +7 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The Monetary Value of Human Life Losses Associated with COVID-19 in Africa: A Human Capital Approach

Economies
Background: By 30 June 2021, the 54 African sovereign nations had reported 5,465,790 laboratory-confirmed COVID-19 cases (including 142,171 deaths). This study aimed to estimate the monetary value of human life losses, indirect and direct costs, and the ...
Joses Muthuri Kirigia, Germano Mwabu
doaj   +1 more source