Results 301 to 310 of about 2,261,504 (355)

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Heterogenous mitochondrial ultrastructure and metabolism of human glioblastoma cells

Bogataj, Urban, Novak, Metka, Galun, Simona Katrin, Fon Tacer, Klementina, Vittori, Miloš, Noorden, Cornelis J. F. van, Breznik, Barbara   +6 more
openalex   +1 more source

Study on Distribution and Metabolism of ~(125)I-recombinant Human Thrombopoietin in Mice

, 2007
Song Jing
openalex   +1 more source

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Human chylomicron apolipoprotein metabolism

Biochemical and Biophysical Research Communications, 1978
Abstract Chylomicron apolipoprotein metabolism was studied utilizing chylomicrons isolated from the pleural fluid of a patient with a recurrent chylous pleural effusion. Chylomicrons contained apolipoproteins A-I, A-II, B, C-I, C-II, C-III, D, E, and albumin.
E J, Schaefer, L L, Jenkins, H B, Brewer
openaire   +2 more sources

Early human embryo metabolism

BioEssays, 1993
AbstractNon‐invasive microanalytical methods have been devised to study the energy metabolism of single human preimplantation embryos. Psyruvate, which is added routinely to all media used to culture human embryos, is consumed throughout the preimplantation period, with glucose assuming an increasing role at embryo compaction and blastocyst formation ...
H J, Leese, J, Conaghan, K L, Martin, K, Hardy   +3 more
openaire   +2 more sources

Ammonium metabolism in humans

Metabolism, 2012
Free ammonium ions are produced and consumed during cell metabolism. Glutamine synthetase utilizes free ammonium ions to produce glutamine in the cytosol whereas glutaminase and glutamate dehydrogenase generate free ammonium ions in the mitochondria from glutamine and glutamate, respectively.
Maria M, Adeva, Gema, Souto, Natalia, Blanco, Cristóbal, Donapetry   +3 more
openaire   +2 more sources

HUMAN METABOLISM OF CYPROHEPTADINE

Drug Metabolism and Disposition, 1975
Gas-liquid chromatographic and mass, nuclear magnetic resonance, and infrared spectrometric techniques were utilized to identify some of the metabolites of cyproheptadine in the urine of human subjects who had ingested radiolabeled drug. Aromatic ring hydroxylation (followed by glucuronide conjugation), N-demethylation, and heterocyclic ring oxidation ...
C C, Porter, B H, Arison, V F, Gruber, D C, Titus, W J, Vandenheuvel   +4 more
openaire   +2 more sources

Human cardiac metabolism

Cell Metabolism
The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans.
Marc R. Bornstein, Rong Tian, Zoltan Arany   +2 more
openaire   +2 more sources

Human Pyrimidine Metabolism

JAMA: The Journal of the American Medical Association, 1966
Studies of pyrimidine metabolism in man have assumed interest in recent years with the recognition of specific alterations in their synthesis and excretion in certain diseases. Further, several pyrimidine antimetabolites have been introduced into cancer chemotherapy, and the metabolic alterations produced by some of these, 6-azauridine, has been a ...
openaire   +2 more sources