Results 91 to 100 of about 160,297 (282)

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

VALUE PERCEPTIONS OF PRACTICES AT A HUMAN MILK BANK

Cogitare Enfermagem, 2017
This study was aimed at identifying and analyzing the value perceptions of health professionals working at the Human Milk Bank about their practices. A descriptive and qualitative study was undertaken.
Tuâny Figueiredo Marinho, Valdecyr Herdy Alves, Maria Bertilla Lutterbach Riker Branco, Diego Pereira Rodrigues, Rosângela de Mattos Pereira, Giovanna Rosario Soanno Marchiori   +5 more
doaj   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

Amamentar e doar leite: percepções das mulheres doadoras de um Banco de Leite Humano

Revista Educação em Saúde, 2018
Objective: To describe and analyze the factors that facilitate the donation of breast milk as well as the difficulties in the perspective of the women donor.
Mateus Guilhardi Rosa e Silva, Karen Cristine Almeida Barbosa, Lorrayne Aparecida Silveira Borges, Guilherme Ferreira Barros, Lucas Gundim Cardoso, Marluce Martins Machado da Silveira   +5 more
doaj   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Evaluation of home collection performed by a human milk bank in a university hospital in Brazil.

Salud Pública de México, 2014
Objective. Evaluation of procedures during household milking and transport of human milk associated with their quality control. Materials and methods.
Glória Menezes, Lígia de Lima-Cavalcanti, Angela Maria de Morais-Oliveira, Rogério de Melo Costa-Pinto, Vânia Olivetti Steffen-Abdallah   +4 more
doaj   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Induced lactation in a transgender woman: case report

International Breastfeeding Journal
Background Breastfeeding offers significant health benefits, but its practice and success can vary. While research on induced lactation in cisgender women has been documented, there is limited research on lactation induction in transgender women.
Shin Ikebukuro, Miori Tanaka, Mei Kaneko, Midori Date, Sachiko Tanaka, Hitomi Wakabayashi, Masahiko Murase, Noriko Ninomiya, Taro Kamiya, Mariko Ogawa, Daisuke Shiojiri, Nahoko Shirato, Yuki Sekiguchi, Akihiko Sekizawa, Mikiya Nakatsuka, Hiroyuki Gatanaga, Katsumi Mizuno   +16 more
doaj   +1 more source

Milk Bank Pooling Practices Impact Concentrations and Variability of Bioactive Components of Donor Human Milk

Frontiers in Nutrition, 2020
Background: Donor human milk (DHM) bank practices, such as pasteurization and pooling according to postpartum age of milk donations and number of donors included in a pool may impact the resulting concentration of bioactive components of DHM.
B. Young, Katherine Murphy, L. L. Borman, R. Heinrich, N. Krebs   +4 more
semanticscholar   +1 more source