Results 51 to 60 of about 8,130,292 (227)

A Review of the Current Status, Challenges, and Opportunities of Human Milk Banks in Africa for Reducing Infant Mortality

Women
Human milk is recognized as the optimal nutrition for infants, with evidence showing it can prevent childhood death. While there are approximately 756 milk banks worldwide, predominantly located in high-income countries, human milk banking remains ...
Barnabas Obeng-Gyasi, Tyler M. Nolting, Kourtney Byrd, Emmanuel Obeng-Gyasi, Cecilia S. Obeng   +4 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Characteristics of the First Human Milk Bank in Taiwan

Pediatrics and Neonatology, 2013
The benefits of feeding human milk to infants, even in prematurity, have been well documented. Well-organized donor milk processing has made the milk bank a good source of nutrition for premature or sick infants if their own mother's milk is not ...
Fang-Yuan Chang, Shao-Wen Cheng, Tsung-Zu Wu, Li-Jung Fang   +3 more
doaj   +1 more source

Effect of human milk banking on immediate neonatal morbidity and mortality: A study in a tertiary care center

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Introduction: Human milk banking (HMB) is a service established for collection, screening, processing, storage, and distribution of donated human milk. HMB is the best way of ensuring a safe supply of human milk to all the needy neonates.
Shailaja Vijaykumar Mane, Shradha Salunkhe, Sharad Agarkhedkar, Priyanka Lakhwani, Sudhir Malwade   +4 more
doaj   +1 more source

Attitudes and Views Concerning Human Milk Banking Among Mothers Residing in a Rural Region of Bangladesh. [PDF]

, 2022
BACKGROUND: Human milk banks play an essential role by providing human milk to infants who would otherwise not be able to receive mother's milk. STUDY AIM: To determine the opinions and attitudes among possible donor mothers regarding human milk banks in
Sm-Rahman, Atiqur, Jahan, Yasmin, Shamsi, Tasdidaa,, Jahan, Yasmin,, Rahman, Sohel, sm-Rahman, Atiqur; id_orcid, Rahman, S M Atiqur,, Shamsi, Tasdidaa, Rahman, Sohel,   +8 more
core   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Acceptability of donated breast milk among pregnant women in selected hospitals in central Uganda: a cross-sectional study

International Breastfeeding Journal, 2023
Background Donated breast milk is considered beneficial to vulnerable infants. Thus, Uganda launched its first human milk bank in November 2021 to provide breast milk to preterm, low birthweight and sick babies.
Mary Gorreth Namuddu, Juliet Kiguli, Victoria Nakibuuka, Ritah Nantale, David Mukunya   +4 more
doaj   +1 more source