Results 71 to 80 of about 10,796,113 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predicting commuter flows in spatial networks using a radiation model based on temporal ranges

, 2014
Understanding network flows such as commuter traffic in large transportation networks is an ongoing challenge due to the complex nature of the transportation infrastructure and of human mobility.
Ercsey-Ravasz, Mária, González, Marta C., Ren, Yihui, Toroczkai, Zoltán, Wang, Pu   +4 more
core   +1 more source

Human mobility monitoring in very low resolution visual sensor network [PDF]

, 2014
This paper proposes an automated system for monitoring mobility patterns using a network of very low resolution visual sensors (30 30 pixels). The use of very low resolution sensors reduces privacy concern, cost, computation requirement and power ...
Aghajan, Hamid, Deboeverie, Francis, Eldib, Mohamed, Guan, Junzhi, Kleihorst, Richard, Niño Castañeda, Jorge, Nyan, Bo Bo, Philips, Wilfried, Slembrouck, Maarten, Steendam, Heidi, Van de Velde, Samuel, Van Haerenborgh, Dirk, Veelaert, Peter, Xie, Xingzhe   +13 more
core   +3 more sources

Human Mobility and Crime: Theoretical Approaches and Novel Data Collection Strategies.

annual review of criminology, 2021
This review outlines approaches to explanations of crime that incorporate the concept of human mobility-or the patterns of movement throughout space of individuals or populations in the context of everyday routines-with a focus on novel strategies for ...
Christopher R. Browning, Nicolo P. Pinchak, Catherine A. Calder   +2 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of Fatiguing Wheelchair Propulsion and Weight Relief Lifts on Subacromial Space in Wheelchair Users

Frontiers in Rehabilitation Sciences, 2022
ObjectiveThis study aimed to identify targets of intervention for reducing shoulder pain in wheelchair users with spinal cord injury (SCI) by (1) examining changes in subacromial space [acromiohumeral distance (AHD) and occupation ratio (OccRatio)] with ...
Ursina Arnet, Michael L. Boninger, Ann Cools, Fransiska M. Bossuyt, Fransiska M. Bossuyt   +4 more
doaj   +1 more source

A stochastic model of randomly accelerated walkers for human mobility [PDF]

, 2015
The recent availability of large databases allows to study macroscopic properties of many complex systems. However, inferring a model from a fit of empirical data without any knowledge of the dynamics might lead to erroneous interpretations [6].
Barthelemy, Marc, Bazzani, Armando, Gallotti, Riccardo, Rambaldi, Sandro   +3 more
core   +5 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Customer mobility and congestion in supermarkets

, 2019
The analysis and characterization of human mobility using population-level mobility models is important for numerous applications, ranging from the estimation of commuter flows in cities to modeling trade flows between countries.
Beguerisse-Díaz, Mariano, Howison, Sam D., Porter, Mason A., Wallis, Alisdair O. G., Ying, Fabian   +4 more
core   +1 more source

Phase transitions in contagion processes mediated by recurrent mobility patterns [PDF]

, 2011
Human mobility and activity patterns mediate contagion on many levels, including the spatial spread of infectious diseases, diffusion of rumors, and emergence of consensus.
A Barrat, A Barrat, A Rapoport, A Vázquez, AL Lloyd, AL Lloyd, Alessandro Vespignani, AN Tabah, BM Bolker, BM Bolker, C Song, C Song, D Balcan, D Balcan, D Brockmann, D Watts, DJ Daley, Duygu Balcan, F Ball, G Chowell, J Marro, K Dietz, L Hufnagel, L Sattenspiel, LA Rvachev, M Barthélemy, M Catanzaro, M Molloy, MC González, MJ Keeling, MJ Keeling, NG van Kampen, NT Bailey, P Cross, P Cross, P Wang, R Cohen, R Guimerá, R Pastor-Satorras, R Patuelli, RF Grais, RM May, S Ni, TE Harris, V Colizza, V Colizza, V Colizza, V Colizza, W Goffman, W Goffman, Y Ben-Zion   +50 more
core   +1 more source