Results 131 to 140 of about 1,294,119 (266)

8 years of strengthening AMR response capacity in the WHO African region (2017-2024): progress in antimicrobial consumption monitoring, surveillance and laboratory capacity. [PDF]

BMJ Public Health
Gahimbare L, Iwu-Jaja C, Mazengiya YD, Coulibaly SO, Lugor LRZ, Mwamelo AJ, Olu OO, Yahaya AA.   +7 more
europepmc   +1 more source

Counterfactual error-monitoring in human planning.

Human decision-making involves evaluating choices and learning from outcomes, yet how individuals process information about paths previously or no longer available options remains unclear. While traditional reinforcement learning models suggest that evaluating unchosen options optimizes future decisions, online planning algorithms typically ignore ...
Yu, Doris, Callaway, Frederick, Mattar, Marcelo G   +2 more
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Large language models require a new form of oversight: capability-based monitoring. [PDF]

NPJ Digit Med
Kellogg KC, Ye B, Hu Y, Savova GK, Wallace B, Bitterman DS.   +5 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Flexible bioelectronic sensors promote the advancement of wearable ultrasound technology in the medicine. [PDF]

Microsyst Nanoeng
Li J, Li G, Ma C, Li W, Yu G, Xiang L, Yao G.   +6 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Beyond Model Development in Healthcare AI: Post-Development Robustness, Post-Deployment Monitoring, and Lifecycle Governance-A Scoping Review of Reviews. [PDF]

Healthcare (Basel)
El Arab RA, Mustafa MH, Almagharbeh WT, Saleem NH, Al Abdulmohsen S, Boathab R, Bu Washl M.   +6 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Clinical trials for continuously monitored and updated AI systems. [PDF]

Nat Med
van Amsterdam WAC, Oberst M, Feng J, Wiens J, Tang S, Joshi S, Ranganath R, Sendak M, Shalit U, Vogt JE, Beaulieu-Jones B, Mamdani M, Kent D, Heagerty PJ, Fleming TR, Goldenberg A.   +15 more
europepmc   +1 more source