Results 41 to 50 of about 1,285,913 (267)

Antecedents of self-reported safety behaviors among commissioning workers in nuclear power plants: The roles of demographics, personality traits and safety attitudes

Nuclear Engineering and Technology, 2021
Demographics, personality traits and attitudes are related to safety behaviors in varied workplaces, but their roles in nuclear power plants (NPPs) have not been fully understood.
Da Tao, Zhaopeng Liu, Xiaofeng Diao, Haibo Tan, Xingda Qu, Tingru Zhang   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Shrunken Median Location Effect Estimates: An Application to Immuno-Oncology

Journal of Probability and Statistics
A robust and efficient estimator of differences in location between two groups across a panel of analytes is introduced. Robustness is provided through the use of medians, and efficiency is provided through mean square error optimal linear shrinkage ...
Tyson H. Holmes, Daniel Wayne Eller, Joshua Barnett, Holden T. Maecker   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Health risk assessment of oral exposure to 9 metals/ metalloids in drinking water for adults in Zibo, Shandong Province

环境与职业医学
BackgroundOral exposure to metals/metalloid elements in drinking water may be harmful to human health.ObjectiveTo assess potential health risks of oral exposure to 9 metals/metalloids in drinking water in Zibo City of Shandong Province from 2019 to 2023,
Sha ZHU, Yi HE, Hui GAO, Tong CHANG, Tao WANG, Cheng PENG   +5 more
doaj   +1 more source

The role of the human cerebellum in performance monitoring [PDF]

Current Opinion in Neurobiology, 2016
While the cerebellum has traditionally been thought of as mainly involved in motor functions, evidence has been accumulating for cerebellar contributions also to non-motor, cognitive functions. The notion of a cerebellar internal model underlying prediction and processing of sensory events and coordination and fine-tuning of appropriate responses has ...
Jutta Peterburs, John E Desmond
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Procedimiento administrativo e inteligencia artificial

Revista Vasca de Administración Pública
In this paper we want to address the need to take on board the advantages of artificial intelligence in the administrative procedure, while adopting the necessary precautions for the protection of the rights of the persons involved in the procedure ...
Roberto González de Zárate Lorente
doaj   +1 more source