Results 81 to 90 of about 1,294,119 (266)

A transparent four-feature speech model for depression screening applicable across clinical and community settings, including assisted-living environments

Frontiers in Digital Health
Depression in older adults, often underrecognized and frequently conflated with cognitive symptoms, remains a major challenge in settings such as assisted-living communities.
Kevin Mekulu, Faisal Aqlan, Hui Yang
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

Frontiers in Aging Neuroscience
Early-stage Alzheimer's disease (AD) remains difficult to assess using conventional linguistic or cognitive assessments, which often overlook subtle and individualized disruptions in speech.
Kevin Mekulu, Faisal Aqlan, Hui Yang
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Proof-of-concept model for instantaneous heart rate-drift correction during low and high exercise exertion

Frontiers in Physiology
Introduction: This study aimed to model below and above anaerobic threshold exercise-induced heart rate (HR) drift, so that the corrected HR could better represent V̇O2 kinetics during and after the exercise itself.Methods: Fifteen healthy subjects (age:
Gabriele B. Papini, Gabriele B. Papini, Alberto G. Bonomi, Francesco Sartor, Francesco Sartor   +4 more
doaj   +1 more source

Highly Sensitive E-Textile Strain Sensors Enhanced by Geometrical Treatment for Human Monitoring. [PDF]

Sensors (Basel), 2020
Vu CC, Kim J.
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

CharMark: character-level Markov modeling for interpretable linguistic biomarkers of cognitive decline

Frontiers in Digital Health
Dementia, one of the most prevalent neurodegenerative diseases, affects millions worldwide. Understanding linguistic markers of dementia is crucial for elucidating how cognitive decline manifests in speech patterns.
Kevin Mekulu, Faisal Aqlan, Hui Yang
doaj   +1 more source

CNN Inference acceleration using low-power devices for human monitoring and security scenarios. [PDF]

Comput Electr Eng, 2020
Mas J, Panadero T, Botella G, Del Barrio AA, García C.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source