Results 41 to 50 of about 9,974,715 (252)

An fMRI study of joint action – varying levels of cooperation correlates with activity in sensorimotor control, but not mentalization, networks

Frontiers in Human Neuroscience, 2012
As social agents, humans continuously interact with with the people around them. Here, motor cooperation was investigated by designing a situation in which pairs of participants, one being scanned with fMRI, controlled jointly a visually presented object
Thierry eChaminade, Jennifer L Marchant, Jennifer L Marchant, Jennifer L Marchant, James eKilner, Christopher D Frith, Christopher D Frith, Christopher D Frith   +7 more
doaj   +1 more source

Plasticity of Synaptic Transmission in Human Stem Cell-Derived Neural Networks

iScience, 2020
Summary: Long-term potentiation and depression, inferred from analysis on brain slices, are considered the cellular processes underlying learning and memory formation. They have not so far been demonstrated in human stem cell-derived neurons.
Yi Dong, Man Xiong, Yuejun Chen, Yezheng Tao, Xiang Li, Anita Bhattacharyya, Su-Chun Zhang   +6 more
doaj   +1 more source

Cortical oscillations that underlie visual selective attention are abnormal in adolescents with cerebral palsy

Scientific Reports, 2021
Adolescence is a critical period for the development and refinement of several higher-level cognitive functions, including visual selective attention.
Rashelle M. Hoffman, Christine M. Embury, Brandon J. Lew, Elizabeth Heinrichs-Graham, Tony W. Wilson, Max J. Kurz   +5 more
doaj   +1 more source

Data-driven models in human neuroscience and neuroengineering.

Current Opinion in Neurobiology, 2019
Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable ...
Bingni W. Brunton, M. Beyeler
semanticscholar   +1 more source

Human V6 Integrates Visual and Extra-Retinal Cues during Head-Induced Gaze Shifts

iScience, 2018
Summary: A key question in vision research concerns how the brain compensates for self-induced eye and head movements to form the world-centered, spatiotopic representations we perceive.
Andreas Schindler, Andreas Bartels
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Spinal cord microstructural changes are connected with the aberrant sensorimotor cortical oscillatory activity in adults with cerebral palsy

Scientific Reports, 2022
Previous animal models have illustrated that reduced cortical activity in the developing brain has cascading activity-dependent effects on the microstructural organization of the spinal cord.
Michael P. Trevarrow, Anna Reelfs, Sarah E. Baker, Rashelle M. Hoffman, Tony W. Wilson, Max J. Kurz   +5 more
doaj   +1 more source

Skill and self-knowledge: empirical refutation of the dual-burden account of the Dunning–Kruger effect

Royal Society Open Science, 2022
For many intellectual tasks, the people with the least skill overestimate themselves the most, a pattern popularly known as the Dunning–Kruger effect (DKE).
Robert D. McIntosh, Adam B. Moore, Yuxin Liu, Sergio Della Sala   +3 more
doaj   +1 more source