Results 161 to 170 of about 53,997 (201)

Human platelet antigen‐1a antibodies induce the release of the chemokine RANTES from human platelets

Vox Sanguinis, 2001
Background and ObjectiveBinding of human platelet antigen‐1a (HPA‐1a)‐specific antibodies to target platelets can trigger platelet activation and mediator release. Here we tested the effect of HPA‐1a antibody‐containing sera on platelet release of the chemokine RANTES (regulated on activation, normal, T‐cell expressed, and presumably secreted) in vitro.
M, Dettke, M, Dreer, P, Höcker, S, Panzer   +3 more
openaire   +2 more sources

Human platelet antigen‐1 (Zw) typing using PCR‐RFLP

Transfusion Medicine, 1993
Summary. The agreement between human platelet antigen‐1 typing with polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) and typing with a serological ELISA method was evaluated. A total of 82 individuals were typed and an absolute correlation was found between the two typing methods.
B R, Andersen, J, Georgsen, H O, Madsen, E, Taaning, N, Grunnet, A, Svejgaard   +5 more
openaire   +2 more sources

Establishment of reference panel for human platelet antigen genotyping

Vox Sanguinis, 2014
Background and ObjectivesHuman platelet antigens (HPAs) are platelet‐specific alloantigens associated with polymorphisms of platelet surface glycoproteins (GPs), and they can induce alloantibodies when individuals lacking a particular polymorphism are exposed to them via pregnancy or transfusion.
R S, Li, Z L, Qiao, B, Ling, P, Lu
openaire   +2 more sources

Presence of P Blood Group Antigens on Human Platelets

American Journal of Clinical Pathology, 1985
Except for ABH antigens, the presence of red cell (RBC) antigens on human platelets has been a source of disagreement among investigators. Because ABH antigens share precursor sequences with P-system saccharides, the authors examined human platelets for evidence of P blood group antigens.
R A, Dunstan, M B, Simpson, W F, Rosse
openaire   +2 more sources

Distribution of human platelet antigens in a Chinese population

Tissue Antigens, 1998
Abstract: We report the distribution of the human platelet antigens HPA‐1, ‐2, ‐3, ‐4 and ‐5 as determined using the polymerase chain reaction with sequence‐specific primers in 100 random, healthy Chinese in Hong Kong. The HPA‐1a, ‐2a, ‐4a and ‐5a genes were present in every sample tested, HPA‐1b, ‐2b and ‐5b were rare, and the sample was monomorphic ...
Y W, Chang, J, Mytilineos, G, Opelz, B R, Hawkins   +3 more
openaire   +2 more sources

Retention of HLA Antigens on Previously Frozen Human Platelets

Transfusion, 1980
Recent technical achievements allow satisfactory cryopreservation of human platelets that, after thawing and washing, maintain functional viability for therapeutic use. We have now demonstrated that such previously frozen platelets retain full HLA antigenic activity in spite of the combination of freezing, thawing, and washing procedures and the ...
M S, Pollack, C G, Zaroulis, J, Klainbard, I Z, Leiderman, B, Dupont   +4 more
openaire   +2 more sources

Human platelet antigen allele frequencies in different Algerian populations

Tissue Antigens, 2010
The frequencies of human platelet antigens (HPAs) vary between different populations and are a major determinant for the prevalence of HPA alloimmunization and its clinically associated entities. No report on HPA prevalence has previously been published for the Algerian populations which are ethnically diverse.
H, Brouk, L, Halle, G, Bertrand, F Z, Neche, H, Ouelaa, C, Kaplan   +5 more
openaire   +2 more sources

PORCINE PLATELET ANTIGENS RECOGNIZED BY HUMAN XENOREACTIVE NATURAL ANTIBODIES

Transplantation, 1994
Hyperacute xenograft rejection of porcine organs by primates is initiated by the binding of recipient natural antibodies to endothelium in the donor organ. We showed previously that human natural antibodies recognize 3 porcine endothelial cell glycoproteins with molecular masses of 115 kDa, 125 kDa, and 135 kDa; we called the glycoproteins gp115/135 ...
J L, Platt, Z E, Holzknecht
openaire   +2 more sources

Human platelet antigens frequencies in Maori and Polynesian populations

Transfusion Medicine, 2013
SUMMARYBackgroundAllele frequencies of human platelet antigens (HPA) reflect population history and possibility of platelet‐specific alloimmunization. Here, we report on screening of variants at HPA loci for Polynesian and Maori subjects.ObjectivesOur aims are to evaluate new HPA genotyping methods, compile and analyse new HPA datasets for these ...
Edinur, H., J Dunn, P., Lea, Rodney, hambers, G.   +3 more
openaire   +3 more sources

Noninvasive fetal genotyping of human platelet antigen-1a.

BJOG : an international journal of obstetrics and gynaecology, 2011
We describe a reliable noninvasive fetal human platelet antigen (HPA)-1a genotyping assay on a real-time polymerase chain reaction (PCR) platform using cell-free fetal DNA isolated from maternal blood. Nonspecific amplification of maternal cell-free DNA is overcome by pre-PCR digestion of the cell-free DNA with the Msp1 restriction enzyme.
Scheffer, P.G., Soussan, A.A., Verhagen, O.J.H.M., Page-Christiaens, G.C.M.L., Oepkes, D., Haas, M. de, Schoot, C.E. van der   +6 more
openaire   +3 more sources