Results 241 to 250 of about 5,283,554 (314)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Potential protein sources for human food

, 1970
Pirie, N. W.
core  

Nonclinical Considerations for Support of Pregnancy and Lactation in Clinical Trials. [PDF]

Birth Defects Res
Stanislaus D, Bowman CJ, Brannen KC, Campion SN, Carlson LM, Chalon S, DeLise AM, Demarta-Gatsi C, Enright BP, Halpern W, Mitchell-Ryan S, Sutherland V, Thacker K, Thompson K, Tornesi B, Van Cruchten S, Wange RL, White T, Chen CL.   +18 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection. [PDF]

Cartilage
Mazzini G, Tuerlings M, van der Stap V, Boone I, Mahdad R, Ramos YFM, Meulenbelt I.   +6 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Aurora-Associated Geomagnetic Activity and Health: A Review With Focus on Neurological Implications. [PDF]

Geohealth
Sethi Y, Vora V, Verma A, Bhatt R, Chaudhary MS, Chopra H, Greig NH.   +6 more
europepmc   +1 more source

Primed Avian Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Restore Granulosa Cell Homeostasis in a CTX-Induced POI-like Dysfunction Model Under Human Menopausal Gonadotropin Stimulation. [PDF]

Int J Mol Sci
Dong HC, Su KM, Lin CK, Cheng HR, Yin CH, Chang FW.   +5 more
europepmc   +1 more source

Environmental Micro-Nanoplastics and Musculoskeletal Disorders: Current Research and Insights. [PDF]

Int J Nanomedicine
Ju C, Dong H, Liu R, Ma Y, Luo R, Hu H.
europepmc   +1 more source