Results 171 to 180 of about 1,491,738 (312)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Polymorphisms in the WNK1 gene are asociated with blood pressure variation and urinary potassium excretion

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Hoti, M, Caulfield, M, Lee, K, Samani, NJ, Elliott, P, Collins, R, Org, E, Farrall, M, Newhouse, S, Juhanson, P, Connell, JM, Ji, C, Burke, B, Viigimaa, M, Shaw-Hawkins, S, Veldre, G, Dobson, R, Kumari, M, Lathrop, GM, Iacone, R, Brunner, E, Dominiczak, AF, Strazzullo, P, Eyheramendy, S, Onipinla, A, Clarke, R, Chambers, J, Howard, P, Cappucio, FP, Marmot, M, Munroe, PB, Wallace, C, Kooner, J, Brown, M, Laan, M   +34 more
core  

Shifts in coral reef fish populations linked to human pressure and tourism activities revealed by COVID-19 restrictions

, 2023
Gairin E, Bertucci F, Roux N, Minier L, Berthe C, Waqalevu V, Maueau T, Sturny V, Sang GT, Mills SC, Lecchini D.   +10 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Mise en évidence d'indicateurs de la dynamique biogéographique en moyenne montagne pyrénéenne par analyses multiscalaire et multitemporelle de photographies aériennes et d'images satellitaires

Cybergeo, 2000
Gilles Selleron, Franck Vidal
doaj   +1 more source

Legacy of the Lost and Pressure of the Present: Malagasy Plant Seeds Retain Megafauna Dispersal Signatures but Downsize Under Human Pressure. [PDF]

Ecol Lett
Pu Y, Zizka A, Onstein RE.
europepmc   +1 more source

The vapour pressure of normal human blood [PDF]

The Journal of Physiology, 1930
openaire   +2 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake human subjects

, 2008
In order to understand the central neural processes involved in blood pressure regulation we recorded muscle sympathetic nerve activity (MSNA) via a tungsten microelectrode in the common peroneal nerve while performing functional Magnetic Resonance ...
Vaughan Macefield, Luke Henderson
core   +1 more source

Ecological similarity governs non-native fish establishment while human pressure and native diversity shape invasion richness. [PDF]

Sci Adv
Xu M, Fang M, Usoof AM, Mandrak NE, Chu C, Qian H, Cao Y, Liu C, Cuthbert RN, Li SP, Su G, Tedesco PA, Dick JTA, Wei H, Yu F, Shu L, Wang X, Mu X, Gu D.   +18 more
europepmc   +1 more source