Results 81 to 90 of about 690,254 (288)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Towards a psychology of machines: large language models predict human memory [PDF]

PeerJ Computer Science
Large language models (LLMs), such as ChatGPT, have shown remarkable abilities in natural language processing, opening new avenues in psychological research.
Elanur Ulakci, Jan Pascal Göbel, Markus Huff   +2 more
doaj   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Synchronic and Diachronic Predictors of Socialness Ratings of Words

Journal of Language and Education
In recent works, a new psycholinguistic concept has been introduced and studied that is the socialness of a word. In particular, Diveica et al., 2022 presents a dictionary with socialness ratings obtained using a survey method.
Владимир Владимирович Бочкарев, Анна Владимировна Шевлякова, Андрей Алексеевич Ачкеев   +2 more
doaj   +1 more source

Generating Labels for Regression of Subjective Constructs using Triplet Embeddings

, 2019
Human annotations serve an important role in computational models where the target constructs under study are hidden, such as dimensions of affect. This is especially relevant in machine learning, where subjective labels derived from related observable ...
Booth, Brandon M., Girault, Benjamin, Mundnich, Karel, Narayanan, Shrikanth   +3 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Why We Need New Evaluation Metrics for NLG

, 2017
The majority of NLG evaluation relies on automatic metrics, such as BLEU . In this paper, we motivate the need for novel, system- and data-independent automatic evaluation methods: We investigate a wide range of metrics, including state-of-the-art word ...
Curry, Amanda Cercas, Dušek, Ondřej, Novikova, Jekaterina, Rieser, Verena   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Memory and subjective workload assessment [PDF]

Recent research suggested subjective introspection of workload is not based upon specific retrieval of information from long term memory, and only reflects the average workload that is imposed upon the human operator by a particular task.
Hart, S., Staveland, L., Yeh, Y. Y.
core   +1 more source