Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Theory of Robot Communication: II. Befriending a Robot over Time
, 2018 In building on theories of Computer-Mediated Communication (CMC), Human-Robot Interaction, and Media Psychology (i.e. Theory of Affective Bonding), the current paper proposes an explanation of how over time, people experience the mediated or simulated ...
Hoorn, Johan F.
core
Human remains from Arma di Nasino (Liguria) provide novel insights into the paleoecology of early Holocene foragers in northwestern Italy. [PDF]
Sci Rep, 2023 Sparacello VS +9 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Comment on Christian’s “Human Capital Accounting in the United States: 1994–2006” [PDF]
Michael Christian's paper presents a human capital account for the United States for the period 1994 to 2006. The main findings are twofold. First, the total human capital stock is about three-quarters of a quadrillion dollars in 2006.
Ellen R. McGrattan
core
Not by the Book: Observations of Delayed Oviposition and Re-Colonization of Human Remains by Blow Flies. [PDF]
Insects, 2022 Owings CG +5 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Human Remains. Interpreting the Past.
Revista do Museu de Arqueologia e EtnologiaSergio F. S. Monteiro da Silva
doaj +1 more source
AABA Task Force on the Ethical Study of Human Remains Recommendations: Proposal for the Management and Oversight of Community Partnership and Ethical Stewardship of Human Remains. [PDF]
Am J Biol AnthropolAuerbach BM +11 more
europepmc +1 more source
As above, so below: Deposition, modification, and reutilization of human remains at Marmoles cave (Cueva de los Marmoles: Southern Spain, 4000-1000 cal. BCE). [PDF]
PLoS One, 2023 Laffranchi Z +9 more
europepmc +1 more source