Results 71 to 80 of about 9,450,007 (227)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Revue Archéologique du Centre de la France, 2009 The rescue excavation of the Marais du Colombier site, Varennes-sur-Seine (Seine-et-Marne) enabled us to study a rural establishment dating back to the first half of the 3rd century BC set in a damp low-lying area of the plain situated in the lower ...
Jean-Marc Séguier +5 more
doaj
Odontopathies in a bronze age human population from Cândeşti (Vrancea county, Romania) [PDF]
Memoirs of the Scientific Sections of the Romanian Academy, 2020 The present study focuses on the odontopathies identified in a sample of human skeletons dating from Middle Bronze Age (Monteoru Culture, 1550–1300 BC), discovered in the necropolis of Cândeşti (Vrancea county, Romania).
Vasilica-Monica Groza +3 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Duties to past persons : The moral standing and posthumous interests of old human remains
, 2012 Research involving human remains presents complex challenges. For the archaeologist or anthropologist, for example, the remains represent among other things a source of knowledge about people and places, conditions and developments.
Masterton, Malin,
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Resolving the Human Remains Crisis in British Archaeology
Papers from the Institute of Archaeology, 2011 Human remains are a fundamental part of the archaeological record, offering unique insights into the lives of individuals and populations in the past.
doaj +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source