Results 161 to 170 of about 12,683,086 (405)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
The Constitution, Treaties, and International Human Rights
, 1968 Louis Henkin
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Milletleraras, 2002 Terrorism, as an institution, targets human rights and democratic states have the right to defend themselves, their citizens and values against terrorism. In a sense, terrorism advantage of the free environment created by the general respect for human rights.
openaire +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
International Recognition and Protection of Fundamental Human Rights
, 1964 C. B. B.
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, 2012 Greetings from Columbia Law School’s Human Rights Institute We are proud to share our first annual report and our remarkable accomplishments from the past year.
Human Rights Institute,
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
, 2014 In recent public and activist debates, threats to the sustainability of the global ecosystem, such as climate change, have increasingly been posed in terms that link the impact on human well-being to questions of rights. Environmental human rights are emerging in national and international legal practice and have been invoked by environmental political
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source