Results 171 to 180 of about 12,628,147 (403)
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
International Human Rights are Taking Hold in U.S. States, Cities, and Towns [PDF]
New York, NY (December 10, 2012) – Incorporating human rights into local policies and decision-making leads to effective, sustainable, and responsive policies, according to a new report released today by Columbia Law School’s Human Rights ...
Human Rights Institute,
core +1 more source
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine+10 more
wiley +1 more source
Civilian Impact of Covert Drone Operations Overlooked [PDF]
WASHINGTON, DC Sept. 30, 2012 — As US covert drone strikes become more entrenched as an accepted counterterrorism strategy, the US government needs to conduct a thorough accounting of the impact on civilians, said a new report released today by Columbia ...
Human Rights Clinic,
core +1 more source
Human Rights in Africa: The Third Biennial Conference of the African Bar Association, Freetown, August 1st-5th, 1978 [PDF]
A.N.A.
openalex +1 more source
Recognition of the human right to peace provides an important link to international criminal law in that it underpins the crime of aggression. The article discusses how the right has developed within the context of debates about amendments to the Rome Statute.
openaire +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte+10 more
wiley +1 more source
A Human Rights Approach to the Labor Rights of Undocumented Workers [PDF]
Neil A. Friedman
openalex +1 more source
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song+11 more
wiley +1 more source