Results 191 to 200 of about 12,497,859 (378)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment

Терапевтический архив, 2010
Aim. To study the epidemiological and clinical features of the 2009-2010 pandemic influenza in Russia. Subjects and methods. Materials from 874 patients, including postmortem samples from 287 subjects, were examined applying the AmpliSens Influenza virus
Svetlana Borisovna Yatsyshina, Andrey Nikolaevich Minenko, Tat'yanaya Evgen'evna Kushakova, Mariya Nikolaevna Praded, Anna Viktorovna Kudryavtseva, German Aleksandrovich Shipulin, Viktor Vasil'evich Maleev, V I Pokrovskiy, S B Yatsyshina, A N Minenko, T E Kushakova, M N Praded, A V Kudryavtseva, G A Shipulin, V V Maleyev, V I Pokrovsky   +15 more
doaj  

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Profit shifting from Nigeria to Europe: The impact on human rights. [PDF]

PLOS Glob Public Health
Etter-Phoya R, Murray S, Hall S, Masiya M, O'Hare B.   +4 more
europepmc   +1 more source

A Health Rights Impact Assessment Guide for Artificial Intelligence Projects [PDF]

Health and Human Rights, 2020
Carmel Williams
doaj  

This alien legacy: the origins of ‘sodomy’ laws in British colonialism [PDF]

, 2013
Human Rights Watch, .
core  

The morals of the market: Human rights and the rise of neoliberalism

Contemporary Political Theory, 2019
Ben Golder
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Dignity and Human Rights-Survey Findings on Undergraduate Nursing Students' Conceptualisation and Operationalisation of Dignity. [PDF]

Nurs Open
Douglas S, Macaden L, Muirhead K, Webster E, Ellis L.   +4 more
europepmc   +1 more source