Results 71 to 80 of about 1,189,722 (360)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Вестник Кемеровского государственного университета, 2014 The paper considers the problem of interaction of non-governmental human rights organizations with political institutions of the Russian Federation, represented by the state authorities, the Ombudsman Institute, the bodies of Internal Affairs, the ...
A. A. Levin
doaj
L’Année du Maghreb, 2009 In Tunisia, the critical concept that allows assessment of relations between the government and human rights organizations and opposition groups active in their midst is the element of compromise.
Larbi Chouikha, Eric Gobe
doaj +1 more source
Effectiveness of international actors in debate of human rights in Iran 1990-2008. [PDF]
, 2011 The Islamic Republic of Iran's (IRI) discourse and practice on human rights issues has raised much criticism in national and international levels.
Davoodifard, Hassan, Jawan, Jayum
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
International legal means of protecting human rights and freedoms
Теорія і практика правознавства, 2019 The article deals with the application of international legal means of protection of human rights and freedoms in Ukraine. The content of the main acts of international law, which guarantee the ability to protect their rights and freedoms from illegal ...
Олександр Миколайович Похил
doaj +1 more source
Labor and Human Rights Organizations call on Government of Bangladesh to Release Worker Rights Advocates [PDF]
, 2010 This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
International Labor Rights Forum
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source