Results 251 to 260 of about 8,954,431 (357)

From consortia discovery to biotech creation: An innovative approach to next-gen Alzheimer's drugs. [PDF]

Alzheimers Dement
Giardina SF, Culver A, Ahmed C, Mirescu C, Oblak AL, Brosch J, Clayton WB, Dage JL, Lamb BT, Richardson TI, Small D, Palkowitz AD.   +11 more
europepmc   +1 more source

Science and the Humanities [PDF]

Science, 1962
openaire   +2 more sources

Science, Social Science, and Humanism [PDF]

The Gerontologist, 1996
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Una Valutazione (Della Ricerca) Dal Volto Umano: La Missione Impossibile Di Andrea Bonaccorsi [The Human Face Of Evaluation Of Science: The Mission Impossible Of Andrea Bonaccorsi]

, 2017
Roberto Caso
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Conservation Challenges and Opportunities for <i>Fokienia hodginsii</i> in the Wuyi Mountains Under Climate Change and Human Influence. [PDF]

Ecol Evol
Luo D, Wang T, Sun J, Guo X, Peng M, Shen H, Qian J.   +6 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Correction: Effect of PM_2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens. [PDF]

Sci Rep
Zhao L, Ding X, Zhou L, Song C, Kang T, Xu Y, Liu Y, Han Y, Zhao W, Zhang B, Xu D, Guo J.   +11 more
europepmc   +1 more source