Results 81 to 90 of about 6,838,489 (312)

The Case for Investing in Disadvantaged Young Children [PDF]

Bildung, Kinder, Pädagogik, Bildungspolitik, Bildungsinvestition, Education, Children, Education sciences, Educational policy, Human capital ...
James J. Heckman
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Historical Linguistics [PDF]

, 2017
Linguists and archaeologists offer complementary viewpoints on human behaviour and culture in past African communities. While historical-comparative linguistics commonly deals with the immaterial traces of the past in Africa’s present-day languages ...
Bostoen, Koen
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Re-establishing Justice as a Pillar of Ecological Economics Through Feminist [PDF]

, 2018
Ecological economics has long claimed distributive justice as a central tenet, yet discussions of equity and justice have received relatively little attention over the history of the field.
Erickson, J.D., Perkins, Patricia E. (Ellie), Spencer, P.   +2 more
core  

Knowledge politics and new converging technologies: a social epistemological perspective [PDF]

, 2009
The “new converging technologies” refers to the prospect of advancing the human condition by the integrated study and application of nanotechnology, biotechnology, information technology and the cognitive sciences - or “NBIC”.
Adleman L.M., Amos M., Arthur W.B., Bainbridge W.S., Bhaskar R., Brenner R., Chatterjee A., Dupré J., Feyerabend P., Fuller S., Fuller S., Fuller S., Galison P., Gilbert W., Glover J., Greenberg D.D., Habermas J., Hacking I., Harris J., Harrison P., Heelan P., Helpman E., Hirst P., Kevles D., Khushf G., Kostoff R., Kostoff R., Kurzweil R., Laudan L., Lenski R., Lukes S., Morange M., Moss L., Nordmann A., Roco M., Roco M., Roco M.C., Rose N., Sandel M., Saracci R., Schmidt J.C., Selin C., Shew A., Singer P., Stehr N., Steve Fuller, Youtie J.   +46 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Language, Culture and Symbolic Forms [PDF]

, 2010
As Ernst Cassierer introduced in his “Philosophie der symbolischen Formen” in 1923, he specifically mentioned “language” as well as a way of symbolic forms.
Theis, Wolfgang
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Revolutionary Seminary and Human Sciences (Necessity and Actions for Change) [PDF]

سپهر سیاست, 2018
Seminaries have been established with an aim to achieve philosophy of prophethood of the Prophets and to recognize, propagate and safeguard Islam and guidance of men and communities and finally, emergence of Islamic civilizations can regarded as their ...
قاسم ترخان
doaj