Results 91 to 100 of about 8,852,242 (348)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Spatial potential evaluation of ecotourism resources and functional zoning in the Qinghai lake basin

Scientific Reports
Existing national park zoning studies exhibits significant gaps in integrating ecological sensitivity, tourism resource potential, and particularly the spatiotemporal dynamics of human activities.
Yishan Xu, Chenxi Wang, Zilin Chen, Nan Liu, Li Zhao, Dongyan Lin, Binqing Zhai, Weile Jiang   +7 more
doaj   +1 more source

Urban “Three States” Human Settlements High-Quality Coordinated Development [PDF]

, 2022
Shenzhen Tian, Ao Qi, Zihang Li, Xiaobai Pan, Liu YuShi, Xueming Li   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The grey-green divide: multi-temporal analysis of greenness across 10,000 urban centres derived from the Global Human Settlement Layer (GHSL)

International Journal of Digital Earth, 2018
The presence of green spaces within city centres has been recognized as a valuable component of the city landscape. Vegetation provides a variety of benefits including energy saving, improved air quality, reduced noise pollution, decreased ambient ...
C. Corbane, M. Pesaresi, P. Politis, A. Florczyk, M. Melchiorri, S. Freire, Marcello Schiavina, D. Ehrlich, G. Naumann, T. Kemper   +9 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Regional Variation of Water Extractable Carbon and Relationships with Climate Conditions and Land Use Types

Agronomy
Water-extractable carbon is thought to originate from labile organic carbon pools and has been used as an active carbon indicator for soil evaluation in numerous studies.
Fan Zhang, Yilin Zhang, Congwen Gui, Xinpei Zhang, Zheng Wang   +4 more
doaj   +1 more source

The settlement option: friend or foe to human rights protection in Africa?

, 2022
Ismene Zarifis
openalex   +2 more sources