Results 71 to 80 of about 8,852,242 (348)

From Traditional Settlements to Arrival Cities: A Study on Contemporary Residential Patterns in Chinese Siheyuan

open access: yesBuildings
With the rapid expansion of Chinese cities, traditional siheyuan in some old urban areas and historic districts have gradually transformed into overcrowded courtyard tenements inhabited primarily by rural migrants.
Mengying Wang   +3 more
doaj   +1 more source

Unveiling 25 Years of Planetary Urbanization with Remote Sensing: Perspectives from the Global Human Settlement Layer

open access: yesRemote Sensing, 2018
In the last few decades the magnitude and impacts of planetary urban transformations have become increasingly evident to scientists and policymakers. The ability to understand these processes remained limited in terms of territorial scope and comparative
M. Melchiorri   +5 more
semanticscholar   +1 more source

Human Settlement Assessment in Jinan From a Facility Resource Perspective

open access: yes, 2020
Multisource data, spatial density analysis, and a gravity model were used to evaluate and analyze differentiation and controls of human settlement locations in Jinan, China. The results indicate the following.
Xueming Li   +4 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Dispatching optimization of city gas station district energy systems with multiple uncertainties based on an improved affine arithmetic method

open access: yesEnergy Reports, 2023
According to the energy consumption characteristics of gas stations, the district energy system (DES) based on natural gas and renewable energy is a suitable form of energy supply.
Tianjie Liu   +3 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Sky type classification in Harbin during winter

open access: yesJournal of Asian Architecture and Building Engineering, 2020
Sky type classification is a significant element in daylight simulation. As a “winter city”, the daylight climate of Harbin is distinctive, and there is therefore a particular need to determine the most appropriate sky models to establish sky luminance ...
Ying Zi, Cheng Sun, Yunsong Han
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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