Results 111 to 120 of about 35,506 (308)

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

open access: yesAdvanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin   +12 more
wiley   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen   +11 more
wiley   +1 more source

Human agency and everyday childhood injury risk : exploring household protective measures for children in ward 7, Epworth (Harare) and Samora Machel (Cape Town)

open access: yes, 2011
[T]his study sought to explore and examine the role of human agency in reducing and managing everyday risks in two African informal settlements through the lens of child injury prevention.
Mavengere, Chiedza Adelaide
core  

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

open access: yesAdvanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan   +10 more
wiley   +1 more source

Health education and medical screening for community well-being in Sriwedari Village

open access: yesAbdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
Eid al-Adha is a religious moment closely associated with the ritual slaughter of sacrificial animals and an increase in red meat consumption among the community.
Indah Tri Lestari   +5 more
doaj   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu   +15 more
wiley   +1 more source

Dogs as sources and sentinels of parasites in humans and wildlife, northern Canada

open access: yes, 2008
A minimum of 11 genera of parasites, including 7 known or suspected to cause zoonoses, were detected in dogs in 2 northern Canadian communities. Dogs in remote settlements receive minimal veterinary care and may serve as sources and sentinels for ...
Brett T. Elkin   +15 more
core   +1 more source

Strengthening communities' capacity through fish crackers processing technology in Konang Village, Lamongan

open access: yesAbdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
Community empowerment plays an important role in strengthening local economic resilience, particularly in coastal areas where fisheries are the main livelihood. In Konang Village, Lamongan, abundant aquaculture production, especially milkfish and tilapia,
Abdul Aziz Jaziri   +3 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

open access: yesAdvanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo   +14 more
wiley   +1 more source

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