Results 121 to 130 of about 426,418 (303)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Topography–Land Surface Temperature Coupling: A Promising Approach for the Early Identification of Coal Seam Fire Zones

ISPRS International Journal of Geo-Information
Coal mining provides energy and economic benefits but also causes environmental damage, including land degradation, pollution, and surface temperature anomalies. Underground coal fires can severely impact the environment, leading to abnormal heat, ground
Yao Wang, Mao-Sheng Zhang, Chuanbo Yang, Da Luo, Ying Dong, Hao Liu, Xu Zhang, Yuteng Yan, Li Feng   +8 more
doaj   +1 more source

Effects of Human Settlements and Spatial Distribution of Wing Vein Length, Wing Fray Categories and Hunger Stages in Glossina morsitans morsitans (Diptera: Glossinidae) and Glossina pallidipes (Diptera: Glossinidae) in Areas Devoid of Cattle in North-Eastern Zambia. [PDF]

J Med Entomol, 2021
Chilongo K, Manyangadze T, Mukaratirwa S.   +2 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

A case study investigation-based experimental research on transport of moisture and salinity in semi-exposed relics

Heritage Science
Semi-exposed relics within an air–soil system often have earthworks partially buried, leading to moisture migration and substantial salt accumulation. Salt accumulation threatens relic preservation, but destructive sampling is hindered by conservation ...
Yike Wang, Jiaxuan Li, Yin Xia, Bin Chang, Xilian Luo   +4 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Research on Low-Carbon Building Design Strategies for Folk Dwellings in Hanzhong Based on Single Objective Optimization

Buildings
With the background of rural revitalization, the urgent demand for energy conservation and improved living quality arises alongside the issues of high energy consumption and low comfort in residential buildings.
Zhichun Yu, Zhenxing Guo, Zihan Ling, Yuren Chen   +3 more
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Chapter 12 - Human settlements, infrastructure and spatial planning [PDF]

, 2014
Urbanization is a process that involves simultaneous transitions and transformations across multiple dimensions, including demographic, economic, and physical changes in the landscape.
Bigio, A., Blanco, H., Delgado, G.C., Dewar, D., Dhakal, S., Huang, L., Inaba, A., Kansal, A., Lwasa, S., McMahon, J., Murakami, J., Müller, D.B., Nagendra, H., Ramaswami, A., Seto, K.C.   +14 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source