Results 121 to 130 of about 7,638,508 (295)
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Housing sector profile studies : Tunisia, Senegal, Uganda and Malawi; final technical report
, 2011 The table of contents for this item can be shared with the requester. The requester may then choose one chapter, up to 10% of the item, as per the Fair Dealing provision of the Canadian Copyright ActThe urban Housing Profile Studies act as both a ...
Acioly, Claudio, D'Aragon, Jean
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Emerging ContaminantsPhthalates (PAEs) exhibit strong adsorption and lipophilicity, yet their adsorption on the blood vessel wall remains unattended. Current PBPK models neglect this adsorptive loss due to the presuming stable blood concentrations. During inhalation exposure,
Haoyu Dang +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Spatiotemporal infiltration characteristics in intact loess: In situ three-dimensional seepage
Journal of Rock Mechanics and Geotechnical EngineeringWater infiltration in loess is one of the most significant processes that can lead to geological disasters on the Loess Plateau in China. However, the spatiotemporal characteristics of infiltration in intact loess, particularly the heterogeneity of three-
Ke Liu, Ling Xu, Zhonghao Sun, Kewen Yu
doaj +1 more source
Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan +7 more
wiley +1 more source
Heritage ScienceSemi-exposed relics within an air–soil system often have earthworks partially buried, leading to moisture migration and substantial salt accumulation. Salt accumulation threatens relic preservation, but destructive sampling is hindered by conservation ...
Yike Wang +4 more
doaj +1 more source
Effects of Human Settlements and Spatial Distribution of Wing Vein Length, Wing Fray Categories and Hunger Stages in Glossina morsitans morsitans (Diptera: Glossinidae) and Glossina pallidipes (Diptera: Glossinidae) in Areas Devoid of Cattle in North-Eastern Zambia. [PDF]
J Med Entomol, 2021 Chilongo K +2 more
europepmc +1 more source