Results 161 to 170 of about 9,709,220 (250)

Intersectional inequalities in healthcare utilisation in informal settlements in Freetown, Sierra Leone: a multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). [PDF]

Int J Equity Health
Sesay IJ, Sesay S, Wurie-Kamara H, Tengbe SM, Fullah S, Vangahun D, Gandi I, de Siqueira Filha NT, Lakshman R, Conteh A, Saidu S, Koroma B, Mansaray B, Elsey H, Whittaker L, Dean L, Georgi NW, Nganda M, Refell F, Macarthy JM, Leyland AH, Tolhurst R, Kibuchi E.   +22 more
europepmc   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Tracing the pathways to Yathrib (Al-Madinah): A GIS-based analysis of settlement patterns and ancient trade networks. [PDF]

PLoS One
Metwaly M, Alshami A.
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

The spread of <i>Echinococcus multilocularis</i> in the Balkans is facilitated by the golden jackal. [PDF]

Front Vet Sci
Uzelac A, Breka K, Penezić A, Pantelić I, Kuručki M, Bogdanović N, Kukurić T, Betić N, Karanović J, Klun I, Ćirović D.   +10 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Household determinants of healthcare utilisation in three informal settlements in Freetown, Sierra Leone: a cross-sectional survey. [PDF]

BMJ Open
Sesay S, Sesay IJ, Tengbe SM, Wurie H, Fullah S, Vangahun D, Gandi I, Teixeira de Siqueira Filha N, Lakshman RWD, Conteh A, Saidu S, Koroma B, Mansaray B, Elsey H, Whittaker L, Dean L, Wiltgen Georgi N, Nganda M, Refell F, MacCarthy J, Leyland AH, Tolhurst R, Kibuchi E.   +22 more
europepmc   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Climate Variability, Urbanization, Water Insecurity, and Cholera in Somalia (2000-2025): A Thematic Narrative Review. [PDF]

Environ Health Insights
Ahmed NI, Abdullahi YB, Bashir SG, Abdi MS, Abdi YH, Osman MM, Hussein SA.   +6 more
europepmc   +1 more source