Results 101 to 110 of about 8,819,593 (390)

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang   +7 more
wiley   +1 more source

The ecclesiastical crisis of human sexuality: ‘Critical solidarity’, ‘critical distance’ or ‘critical engagement’

open access: yesHTS Teologiese Studies/Theological Studies
The issue of human sexuality has many negative implications in African society. These arose in a number of contexts – legal, religious, cultural and societal – and were significantly divisive.
Graham A. Duncan
doaj   +1 more source

Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice

open access: yesAmerican Journal of Men's Health, 2018
Amitriptyline is an old drug but is still prevalently used as the first-line treatment for a variety of common diseases. Surprisingly, knowledge of sexual risks with amitriptyline comes from only one clinical trial and several case reports from three ...
Louis Wei-Hsi Chen MD, MSc, LLM   +7 more
doaj   +1 more source

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat   +8 more
wiley   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao   +10 more
wiley   +1 more source

Can Sexuality Education Advance Gender Equality and Strengthen Education Overall? Learning from Nigeria's Family Life and HIV Education Program [PDF]

open access: yes, 2015
The imperative to prepare the largest generation of young people in history for adulthood has driven a search for fresh approaches to educating adolescents about their bodies and sexuality.
Deborah Rogow, Susan Y. Wood
core  

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski   +13 more
wiley   +1 more source

Ethical beginnings: Reflexive questioning in designing child sexuality research [PDF]

open access: yes, 2013
Counselling young children referred for sexualised behaviour can challenge therapists’ ideas about childhood and sexuality. This area of practice is complex and sensitive, and calls upon collaboration with a range of significant adults in children's ...
Flanagan, Paul G.
core   +2 more sources

Between the Normative and the Performative: Sex, Parody, and Other (In)tractable Issues in Geoffrey Chaucer’s Miller’s Tale

open access: yesMessages, Sages and Ages, 2016
The article explores how Geoffrey Chaucer’s Canterbury Tales discusses human sexuality as a major thematic concern in both its normative and its performative dimension, and sex, an (in)tractable issue throughout the Middle Ages, as a core motif that ...
Popescu Dan Nicolae
doaj   +1 more source

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