Results 41 to 50 of about 374,123 (334)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

open access: yesMolecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef   +10 more
wiley   +1 more source

The Presentation of Postmodern Sexuality in Short Fiction [PDF]

open access: yes, 2018
Shifting norms in twentieth century western society, coupled with emerging postmodern thought in the 1960s, radically changed the ways in which people viewed sexuality, gender roles, and the institutions of marriage and the family.
Kapus, Allie J
core   +1 more source

Sexuality and nationality: homophobic discourse and the 'national threat' in contemporary Latvia [PDF]

open access: yes, 2010
This paper considers why attitudes towards gays and lesbians in Latvia appear to be more intolerant than in all other EU member states. The paper argues that while the legacy of communist discourses on homosexuality and the impact of post-communist ...
Mole, R.C.M.
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

The colonisation of Setswana: A decolonial rereading of the 1840 Gospel of Luke

open access: yesHTS Teologiese Studies/Theological Studies
In his 1840 translation of the Gospel of Luke from English into Setswana, Robert Moffat transfers Western numerals, geographic words and biblical names to Setswana.
Itumeleng D. Mothoagae
doaj   +1 more source

Dr. Ford\u27s Palindromia [PDF]

open access: yes, 1996
Dr. Nemo W. Ford is not exactly at the forefront of human sexuality research in this country. Rather, his work is somewhat on the fringe of accepted practices and clinical techniques. With a \u27Dr.
Woodside, David
core   +1 more source

Functional parameters of spermatozoa obtained by a new selection device

open access: yesFEBS Open Bio, EarlyView.
This study compares density gradient centrifugation and the LensHooke CA0™ device for sperm separation. DGC requires multiple steps, specialized equipment, and technical expertise. In contrast, the CA0 device offers key practical and methodological advantages, resulting in a faster, simpler, and more affordable sperm selection method.
Julio C. Chávez   +8 more
wiley   +1 more source

Biblical discourses and the construction of genders and sexualities in contemporary South Africa: A decolonial analysis

open access: yesHTS Teologiese Studies/Theological Studies
The constructions of genders and sexualities in different global spaces continue to be influenced by Christian and imperial ideologies. In Africa, genders and sexualities were (mis)construed by colonial and missionary enterprises, and they continue to be
Themba Shingange
doaj   +1 more source

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