Results 41 to 50 of about 400,606 (340)
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Societies, 2018 Hans Christian Andersen’s tale, “The Little Mermaid,” has been adored by both children and parents for decades. The tale shows an astonishingly different quality to Andersen’s early genre of fairy tales, which allows the reader to sense his keenness on ...
Seungyeon Lee
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
HTS Teologiese Studies/Theological StudiesThe constructions of genders and sexualities in different global spaces continue to be influenced by Christian and imperial ideologies. In Africa, genders and sexualities were (mis)construed by colonial and missionary enterprises, and they continue to be
Themba Shingange
doaj +1 more source
The Presentation of Postmodern Sexuality in Short Fiction [PDF]
, 2018 Shifting norms in twentieth century western society, coupled with emerging postmodern thought in the 1960s, radically changed the ways in which people viewed sexuality, gender roles, and the institutions of marriage and the family.
Kapus, Allie J
core +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
The colonisation of Setswana: A decolonial rereading of the 1840 Gospel of Luke
HTS Teologiese Studies/Theological StudiesIn his 1840 translation of the Gospel of Luke from English into Setswana, Robert Moffat transfers Western numerals, geographic words and biblical names to Setswana.
Itumeleng D. Mothoagae
doaj +1 more source
Dr. Ford\u27s Palindromia [PDF]
, 1996 Dr. Nemo W. Ford is not exactly at the forefront of human sexuality research in this country. Rather, his work is somewhat on the fringe of accepted practices and clinical techniques. With a \u27Dr.
Woodside, David
core +1 more source
“Disabled people are sexual citizens too”: supporting sexual identity, well-being, and safety for disabled young people [PDF]
, 2017 Disabled young people are sexual beings, and deserve equal rights and opportunities to have control over, choices about and access to their sexuality, sexual expression and fulfilling relationships throughout their lives.
Shah, Sonali
core +2 more sources