Results 61 to 70 of about 8,819,593 (390)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Biblical discourses and the construction of genders and sexualities in contemporary South Africa: A decolonial analysis

open access: yesHTS Teologiese Studies/Theological Studies
The constructions of genders and sexualities in different global spaces continue to be influenced by Christian and imperial ideologies. In Africa, genders and sexualities were (mis)construed by colonial and missionary enterprises, and they continue to be
Themba Shingange
doaj   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga   +8 more
wiley   +1 more source

The Presentation of Postmodern Sexuality in Short Fiction [PDF]

open access: yes, 2018
Shifting norms in twentieth century western society, coupled with emerging postmodern thought in the 1960s, radically changed the ways in which people viewed sexuality, gender roles, and the institutions of marriage and the family.
Kapus, Allie J
core   +1 more source

The colonisation of Setswana: A decolonial rereading of the 1840 Gospel of Luke

open access: yesHTS Teologiese Studies/Theological Studies
In his 1840 translation of the Gospel of Luke from English into Setswana, Robert Moffat transfers Western numerals, geographic words and biblical names to Setswana.
Itumeleng D. Mothoagae
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Dr. Ford\u27s Palindromia [PDF]

open access: yes, 1996
Dr. Nemo W. Ford is not exactly at the forefront of human sexuality research in this country. Rather, his work is somewhat on the fringe of accepted practices and clinical techniques. With a \u27Dr.
Woodside, David
core   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla   +15 more
wiley   +1 more source

Effects of Pornography on Adolescents [PDF]

open access: yes, 2017
Pornography has significant effects during all stages of family life. For a child exposed to pornography within a family setting, pornography causes stress and increases the risk for developing negative attitudes about the nature and purpose of human ...

core  

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