Results 91 to 100 of about 976,647 (347)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects. [PDF]

PLoS ONE, 2012
BackgroundErythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated.
Britt Christensen, Carsten Lundby, Niels Jessen, Thomas S Nielsen, Poul F Vestergaard, Niels Møller, Henriette Pilegaard, Steen B Pedersen, John J Kopchick, Jens Otto L Jørgensen   +9 more
doaj   +1 more source

Functional Classification of Skeletal Muscle Networks. I. Normal Physiology [PDF]

, 2012
Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models.
Subramaniam, Shankar, Wang, Yu, Winters, John   +2 more
core   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle

Molecular Metabolism, 2016
Objective: Recent data suggest that adipose triglyceride lipase (ATGL) plays a key role in providing energy substrate from triglyceride pools and that alterations of its expression/activity relate to metabolic disturbances in skeletal muscle.
Claire Laurens, Pierre-Marie Badin, Katie Louche, Aline Mairal, Geneviève Tavernier, André Marette, Angelo Tremblay, S. John Weisnagel, Denis R. Joanisse, Dominique Langin, Virginie Bourlier, Cedric Moro   +11 more
doaj   +1 more source

Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]

, 2016
Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu, de Paoli, Frank Vincenzo, Nielsen, Ole Bækgaard, Pedersen, Thomas Holm, Riisager, Anders   +4 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Electrical stimulation of biofidelic engineered muscle enhances myotube size, force, fatigue resistance, and induces a fast‐to‐slow‐phenotype shift

Physiological Reports
Therapeutic development for skeletal muscle diseases is challenged by a lack of ex vivo models that recapitulate human muscle physiology. Here, we engineered 3D human skeletal muscle tissue in the Biowire II platform that could be maintained and ...
Isabella Pallotta, Michael J. Stec, Brian Schriver, David R. Golann, Kevin Considine, Qi Su, Victor Barahona, Julia E. Napolitano, Sarah Stanley, Meghan Garcia, Nicole T. Feric, Krista M. Durney, Roozbeh Aschar‐Sobbi, Nathan Bays, Tea Shavlakadze, Michael P. Graziano   +15 more
doaj   +1 more source

Prospective isolation of human fibroadipogenic progenitors with CD73

Heliyon, 2020
Skeletal muscle relies on coordination between myogenic and non-myogenic interstitial cells for homeostasis and for regeneration and response to injury.
Natalya A. Goloviznina, Ning Xie, Abhijit Dandapat, Paul A. Iaizzo, Michael Kyba   +4 more
doaj   +1 more source