Results 51 to 60 of about 8,752,687 (338)

Deciduous enamel 3D microwear texture analysis as an indicator of childhood diet in medieval Canterbury, England [PDF]

open access: yes, 2016
This study conducted the first three dimensional microwear texture analysis of human deciduous teeth to reconstruct the physical properties of medieval childhood diet (age 1-8yrs) at St Gregory's Priory and Cemetery (11th to 16th century AD) in ...
Deter, Chris   +7 more
core   +3 more sources

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Some research possibilities in diagnostic radiography [PDF]

open access: yes, 1998
This is tha author's PDF version of an article published in Radiography© 1998. The definitive version is available at www.elsevierhealth.comAlthough scientific method is usually viewed as starting with hypotheses which must then be exposed to ...
Lewis, Stephen J.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay

open access: yesPLoS ONE, 2023
Nicotinamide adenine dinucleotide (NAD) is a central molecule in cellular metabolism that has been implicated in human health, the aging process, and an array of human diseases.
Karen H. Almeida   +4 more
doaj   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

MoSculp: Interactive Visualization of Shape and Time

open access: yes, 2018
We present a system that allows users to visualize complex human motion via 3D motion sculptures---a representation that conveys the 3D structure swept by a human body as it moves through space.
Dekel, Tali   +7 more
core   +1 more source

Robust Segmentation of Voxel Shapes using Medial Surfaces [PDF]

open access: yes, 2008
We present a new patch-type segmentation method for 3D voxel shapes based on the medial surface, also called surface skeleton. The boundaries of the simplified fore- and background skeletons map one-to-one to increasingly fuzzy, soft convex, respectively
Reniers, Dennie,, Telea, Alexandru,
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Brief Communication: Intertooth and Intrafacet Dental Microwear Variation in an Archaeological Sample of Modern Humans From the Jordan Valley [PDF]

open access: yes, 2006
Dental microwear was recorded in a Bronze-Iron Age (3570–3000 BP) sample of modern humans recovered from Tell es-Sa'idiyeh in the Jordan Valley. Microwear patterns were compared between mandibular molars, and between the upper and lower part of facet 9 ...
Mahoney, Patrick
core   +1 more source

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