Results 61 to 70 of about 8,752,687 (338)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Neolithic and medieval virus genomes reveal complex evolution of hepatitis B
eLife, 2018 The hepatitis B virus (HBV) is one of the most widespread human pathogens known today, yet its origin and evolutionary history are still unclear and controversial.
Ben Krause-Kyora +21 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Mapping diagenesis in archaeological human bones
Heritage Science, 2019 We describe a procedure for ascertaining the extent of diagenesis in archaeological human skeletons through the distribution of Sr, Ba, Cu, Pb, Fe, and Mn in cross-sections of femoral cortical bone.
Kaare Lund Rasmussen +5 more
doaj +1 more source
A Study on 3D Human Pose Estimation Using Through-Wall IR-UWB Radar and Transformer
IEEE Access, 2023 In this paper, we propose a human pose estimation algorithm for an impulse radio ultra-wideband (IR-UWB) radar based on the transformer-based deep learning model.
Gon Woo Kim +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Papers from the Institute of Archaeology, 2012 One of the first jobs for any bone specialist examining an assemblage is to assign an age at death and a sex to the individual skeletons. Having done so, he or she will then construct a table in which the number of skeletons in each of the age and ...
doaj +2 more sources
Anthropometric Aspects Of The Human Skeleton
Journal of Education, Health and Sport, 2017 Wróbel Grzegorz, Spałek Jakub, Zieliński Paweł. Anthropometric aspects of the human skeleton. Journal of Education, Health and Sport. 2017;7(12):602-611. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1141141 http://ojs.ukw.edu.pl/index.php/johs/article/view/5199 https://pbn.nauka.gov.pl/sedno-webapp/works/845929 The journal ...
Grzegorz Wróbel +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Motivating children to learn effectively: exploring the value of intrinsic integration in educational games [PDF]
, 2011 The concept of intrinsic motivation lies at the heart of the user engagement created by digital games. Yet despite this, educational software has traditionally attempted to harness games as extrinsic motivation by using them as a sugar coating for ...
Ainsworth, Shaaron E, Habgood, MP Jacob
core +1 more source