Results 91 to 100 of about 5,103 (239)

Assessing the Readiness for Human Commercial Spaceflight Safety Regulations: Charting a Trajectory from Revolutionary to Routine Travel [PDF]

, 2023
Douglas C. Ligor, Benjamin Miller, Maria McCollester, Brian L. Phillips, G.P. Kirkwood, Josh Becker, Gwen Mazzotta, Bruce McClintock, Barbara Bicksler   +8 more
openalex   +1 more source

Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness

Experimental Physiology, EarlyView.
Abstract Central artery stiffening increases the haemodynamic pulsations transmitted downstream towards target organs, including the brain. While recent evidence suggests that long duration spaceflight is associated with reduced common carotid artery (CCA) distensibility, cerebrovascular pulsatility has not been extensively characterized in astronauts.
Roxanne Fournier, Danielle K. Greaves, J. Kevin Shoemaker, Philippe Arbeille, Richard L. Hughson, Andrew D. Robertson   +5 more
wiley   +1 more source

Simulated Microgravity Induces Apoptosis in Human Lymphocytes by a 5-Lipoxygenase-Mediated Mechanism

Journal of Biological Research, 2003
Experiments performed during spaceflight clearly show that several cellular processes, such as oxidative metabolism, growth rates, signaling pathways and gene expression, are modified under conditions of weightlessness [1].
M. Maccarrone, N. Battista, M. A. Meloni, M. Bari, G. Galleri, P. Pippia, A. Cogoli, A. Finazzi-Agrò   +7 more
doaj   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight

Nature Communications
As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX
Nadia Houerbi, JangKeun Kim, Eliah G. Overbey, Richa Batra, Annalise Schweickart, Laura Patras, Serena Lucotti, Krista A. Ryon, Deena Najjar, Cem Meydan, Namita Damle, Christopher Chin, S. Anand Narayanan, Joseph W. Guarnieri, Gabrielle Widjaja, Afshin Beheshti, Gabriel Tobias, Fanny Vatter, Jeremy Wain Hirschberg, Ashley Kleinman, Evan E. Afshin, Matthew MacKay, Qiuying Chen, Dawson Miller, Aaron S. Gajadhar, Lucy Williamson, Purvi Tandel, Qiu Yang, Jessica Chu, Ryan Benz, Asim Siddiqui, Daniel Hornburg, Steven Gross, Bader Shirah, Jan Krumsiek, Jaime Mateus, Xiao Mao, Irina Matei, Christopher E. Mason   +38 more
doaj   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Spaceflight alters host-gut microbiota interactions

npj Biofilms and Microbiomes
The ISS rodent habitat has provided crucial insights into the impact of spaceflight on mammals, inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy.
E. Gonzalez, M. D. Lee, B. T. Tierney, N. Lipieta, P. Flores, M. Mishra, L. Beckett, A. Finkelstein, A. Mo, P. Walton, F. Karouia, R. Barker, R. J. Jansen, S. J. Green, S. Weging, J. Kelliher, N. K. Singh, D. Bezdan, J. Galazska, N. J. B. Brereton   +19 more
doaj   +1 more source

Web site for human spaceflight review committee [PDF]

, 2009
Randy Showstack
openalex   +1 more source

Close encounters between young people and human spaceflight [PDF]

, 2020
Lynda Dunlop, Jeremy Airey, Maria Turkenburg‐van Diepen, Judith Bennett   +3 more
openalex   +1 more source

Expression of p53-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight [PDF]

, 2012
Akihisa Takahashi, Hiromi Suzuki, Katsunori Omori, Masaya Seki, Tōkō Hashizume, Toru Shimazu, Noriaki Ishioka, Takeo Ohnishi   +7 more
openalex   +1 more source