Results 131 to 140 of about 5,103 (239)

Surgery in space: The ultimate frontier

Experimental Physiology, EarlyView.
Mohamad Bashir, Ali Murtada, Matti Jubouri, Adam Bashir, Ian Williams, Damian Bailey   +5 more
wiley   +1 more source

Long non‐coding RNAs Kcnq1ot1 and Lncpint are involved in skeletal muscle atrophy induced by the space exposome

The Journal of Physiology, EarlyView.
Abstract figure legend Long non‐coding RNAs (lncRNAs) KCNQ1OT1 and LINC‐PINT are upregulated in mouse, human and cell models of spaceflight‐induced muscle atrophy, revealing a novel regulatory role under (simulated) microgravity. Abstract Long non‐coding RNAs (lncRNAs) play an important role in the regulation of skeletal muscle transcriptional ...
Sergio Pérez‐Díaz, Bjorn Baselet, Alen Lovric, Tommy R. Lundberg, Mieke Neefs, Lisa Daenen, Eric Rullman, Rodrigo Fernandez‐Gonzalo   +7 more
wiley   +1 more source

Science of omics: a molecular space odyssey

Experimental Physiology, EarlyView.
Salomé Coppens, Christophe Hirtz, Margaux Vignon, Damian M. Bailey   +3 more
wiley   +1 more source

Analysis of Microbial Diversity and Evidence of Contamination at a Mars Analogue Habitat

Environmental Microbiology Reports, Volume 17, Issue 4, August 2025.
We assessed the potential of a crewed mission to Mars to microbially contaminate the surface by studying a terrestrial analogue facility, the Mars Desert Research Station. DNA sequencing of interior swabs and an external soil sample allowed us to characterise the microbiomes present.
Mara Leite, Dragana Dobrijevic, Michael C. Macey, Mamatha Maheshwarappa, John Ward, Lewis Dartnell   +5 more
wiley   +1 more source

The ultimate exercise countermeasure for long‐duration spaceflight?

Experimental Physiology, EarlyView.
Donald E. Watenpaugh, Alan R. Hargens
wiley   +1 more source

Exploring Outer Radiation Belt Losses From the International Space Station

Geophysical Research Letters, Volume 52, Issue 13, 16 July 2025.
Abstract The precipitation of energetic electrons from the outer radiation belt plays a crucial role in regulating their flux dynamics and influencing ionospheric properties. While theoretical and numerical studies, often based on near‐equatorial spacecraft measurements, are essential for assessing the precipitation efficiency, low‐altitude ...
Xiao‐Jia Zhang, Anton Artemyev, Yuto Katoh, Yikai Hsieh, Vassilis Angelopoulos, Shoji Torii, Ryuho Kataoka, Yosui Akaike, Satoshi Nakahira   +8 more
wiley   +1 more source

Status quo of Experimental Physiology – Anno 2025: What's in a name?

Experimental Physiology, EarlyView.
Damian M. Bailey, David C. Poole, Ronan M. G. Berg   +2 more
wiley   +1 more source

Aging and Altered Gravity: A Cellular Perspective

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven, Jack J. W. A. van Loon   +1 more
wiley   +1 more source

Mitochondrial Calcium Uniporter‐Mediated Regulation of the SIRT3/GSK3β/β‐Catenin Signaling Pathway in Vascular Remodeling

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
In HU and hypertensive rats, MCU expression in cerebral arteries is reduced. This reduction impairs cellular Ca2+ buffering and promotes mitochondrial oxidative stress. The stress response initiates the downstream degradation of SIRT3, which subsequently inhibits the activity of GSK3β via acetylation and promotes the nuclear translocation of β‐catenin,
Min Jiang, Lejian Lin, Shuai Yue, Shujin Shi, Haojie Yan, Hui Yi, Fan Han, Shuai Xu, Junjie Su, Ran Zhang   +9 more
wiley   +1 more source

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. [PDF]

Science, 2019
Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW.   +81 more
europepmc   +1 more source