Results 31 to 40 of about 110,808 (286)

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling [PDF]

open access: yesnpj Microgravity 6(1), 27, 2020, 2020
Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology and push scientific boundaries further. A key area of importance is cardiovascular deconditioning, that is, the collection of hemodynamic changes - from blood volume shift and reduction to ...
arxiv   +1 more source

Hierarchical Reinforcement Learning Framework for Stochastic Spaceflight Campaign Design [PDF]

open access: yesJournal of Spacecraft and Rockets (Articles in Advance), 2022, 2021
This paper develops a hierarchical reinforcement learning architecture for multimission spaceflight campaign design under uncertainty, including vehicle design, infrastructure deployment planning, and space transportation scheduling. This problem involves a high-dimensional design space and is challenging especially with uncertainty present.
arxiv   +1 more source

Psychological and Human Factors in Long Duration Spaceflight

open access: yesMcGill Journal of Medicine, 2020
The spaceflight environment is characterized by temperature extremes, microgravity, solar and galactic cosmic radiation, lack of atmospheric pressure, and high-speed micrometeorites.
Ephimia Morphew
doaj   +1 more source

Spaceflight enhances cell aggregation and random budding in Candida albicans. [PDF]

open access: yesPLoS ONE, 2013
This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions. Microarray analysis revealed that C. albicans subjected to
AurĂ©lie CrabbĂ©   +14 more
doaj   +1 more source

Spaceflight promotes biofilm formation by Pseudomonas aeruginosa. [PDF]

open access: yesPLoS ONE, 2013
Understanding the effects of spaceflight on microbial communities is crucial for the success of long-term, manned space missions. Surface-associated bacterial communities, known as biofilms, were abundant on the Mir space station and continue to be a ...
Wooseong Kim   +10 more
doaj   +1 more source

Monitoring the Impact of Spaceflight on the Human Brain

open access: yesLife, 2022
Extended exposure to radiation, microgravity, and isolation during space exploration has significant physiological, structural, and psychosocial effects on astronauts, and particularly their central nervous system. To date, the use of brain monitoring techniques adopted on Earth in pre/post-spaceflight experimental protocols has proven to be valuable ...
Michael F. Dinatolo, Luchino Y. Cohen
openaire   +3 more sources

Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

open access: yesLife, 2021
There has long been an interest in understanding how the hazards from spaceflight may trigger or exacerbate human diseases. With the goal of advancing our knowledge on physiological changes during space travel, NASA GeneLab provides an open-source ...
Charlotte A. Nelson   +7 more
doaj   +1 more source

Defending Spaceflight - The Echoes of Apollo [PDF]

open access: yes, 2016
This paper defends, and emphasizes the importance of, spaceflight, broadly construed to include human and unmanned spaceflight, space science, exploration and development.
Rovetto, Robert J.
core   +1 more source

Transcriptomic response of bioengineered human cartilage to parabolic flight microgravity is sex-dependent

open access: yesnpj Microgravity, 2023
Spaceflight and simulated spaceflight microgravity induced osteoarthritic-like alterations at the transcriptomic and proteomic levels in the articular and meniscal cartilages of rodents.
A. K. Aissiou   +8 more
doaj   +1 more source

Reimagining Icarus: Ethics, Law and Policy Considerations for Commercial Human Spaceflight [PDF]

open access: yes, 2018
Commercial human spaceflight presents an area for engaging novel human activity and objectives, to include space exploration, entertainment, transportation and extraterrestrial resource acquisition. The inherent dangers and lack of scientific and medical
Langston, Sara M.
core   +2 more sources

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