Results 71 to 80 of about 110,808 (286)

Similarity Assessment of the Engineering Concepts: Decision‐Making Support and Metrics

Systems Engineering, EarlyView.
ABSTRACT The new product development (NPD) process is a systematic approach to bring new products and innovations to market. Nowadays, this process is affected by a number of influencing factors associated with the fast‐paced technological changes. One of those factors is the distributed design nature of product development activities: team members are
Yaroslav Menshenin, Suhail Alsalehi, Markus Guerster, Edward Crawley   +3 more
wiley   +1 more source

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

Nature Communications
The advent of civilian spaceflight challenges scientists to precisely describe the effects of spaceflight on human physiology, particularly at the molecular and cellular level.
Kirill Grigorev, Theodore M. Nelson, Eliah G. Overbey, Nadia Houerbi, JangKeun Kim, Deena Najjar, Namita Damle, Evan E. Afshin, Krista A. Ryon, Jean Thierry-Mieg, Danielle Thierry-Mieg, Ari M. Melnick, Jaime Mateus, Christopher E. Mason   +13 more
doaj   +1 more source

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Life, 2020
Rodent models have been widely used as analogs for estimating spaceflight-relevant molecular mechanisms in human tissues. NASA GeneLab provides access to numerous spaceflight omics datasets that can potentially generate novel insights and hypotheses ...
Shin-ichiro Fujita, Lindsay Rutter, Quang Ong, Masafumi Muratani   +3 more
doaj   +1 more source

Simulated spaceflight-induced cardiac remodeling is modulated by gut microbial-derived trimethylamine N-oxide

iScience, 2023
Summary: Spaceflight is physically demanding and can negatively affect astronauts’ health. It has been shown that the human gut microbiota and cardiac function are affected by spaceflight and simulated spaceflight.
Zizhong Liu, Gui Luo, Ruikai Du, Guanghan Kan, Xuan Han, Guohui Zhong, Wenjuan Xing, Ying Cui, Weijia Sun, Jianwei Li, Yuheng Li, Dingsheng Zhao, Xinxin Yuan, Xiaoyan Jin, Yanping Han, Huiyuan Sun, Shukuan Ling, Yingxian Li   +17 more
doaj  

Basic principles and concept design of a real-time clinical decision support system for managing medical emergencies on missions to Mars [PDF]

arXiv, 2020
Space agencies and private companies prepare the beginning of human space exploration for the 2030s with missions to put the first human on the Mars surface. The absence of gravity and radiation, along with distance, isolation and hostile environments, are expected to increase medical events where previously unseen manifestations may arise. The current
arxiv  

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Towards the Final Frontier: Using Strategic Communication Activities to Engage the Latent Public as a Key Stakeholder in a Corporate Mission [PDF]

, 2018
Private corporations that do not normally interact with, nor regularly communicate with, the public often do not perceive the public as a relevant or active stakeholder.
D\u27Urso, Scott C.
core   +1 more source

Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Therapeutic drug monitoring for astronauts faces limitations in conventional blood sampling and sample management onboard the international space station. Here, we explore the feasibility of dried blood spot (DBS) collection during parabolic flights (PF) to overcome these constraints.
Audrey Derobertmasure, Li Shean Toh, Céline Verstuyft, Srboljub Lukic, Christelle De Sousa Carvalho, Raphaël Couronné, Marie Beauvalet, Stéphanie Chhun, Pierre Boutouyrie   +8 more
wiley   +1 more source

Application of the Monte Carlo Method in Modeling Transport and Acceleration of Solar Energetic Particles [PDF]

arXiv, 2022
The need for quantitative characterization of the solar energetic particle (SEP) dynamics goes beyond being an academic discipline only. It has numerous practical implications related to human activity in space. The terrestrial magnetic field shields the International Space Station (ISS) and most uncrewed missions from exposure to SEP radiation ...
arxiv  

Innovative Technologies for Human Exploration: Opportunities for Partnerships and Leveraging Novel Technologies External to NASA [PDF]

, 2011
Human spaceflight organizations have ambitious goals for expanding human presence throughout the solar system. To meet these goals, spaceflight organizations have to overcome complex technical challenges for human missions to Mars, Near Earth Asteroids ...
Graham, Rachael, Hay, Jason, Mullins, Carie, Reeves, John D., Williams-Byrd, Julie   +4 more
core   +1 more source