Results 161 to 170 of about 287,942 (280)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Recommendations from Multi-Disciplinary Professionals for Survivor-Informed and Comprehensive Care for Human Trafficking Survivors. [PDF]

Healthcare (Basel)
Tsoi CM, Smith TB, Cutrer-Párraga E, Clayton D, Marshall JM, Mastny J.   +5 more
europepmc   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Automated informatics may increase the detection rate of suspicious cases of human trafficking-a preliminary study. [PDF]

JAMIA Open, 2023
Duke DO, Allard D, Dysart S, Hogan KO, Phelan S, Rawlings L, Stoklosa H.   +6 more
europepmc   +1 more source

Human Trafficking Help Line Infographic

Here is a bilingual (English + Spanish) human trafficking helpline sign text that complies with New Jersey state requirements for posting in public restrooms and similar venues.
Global Center on Human Trafficking
core  

Other title: Ohio Trafficking In Persons Study Commission, Prevention, Education and Outreach Subcommittee, Report on strategies to increase awareness of human trafficking in Ohio

, 2010
"October 13, 2010,"; Harvested from the web on 8/21/12Appendix B. Social media and the Ohio Trafficking in Persons Study Commission : utilizing facebook, twitter, and YouTube to combat human trafficking / Alisa Bartel and Alex Kreidenweis (University of ...
Ohio Trafficking in Persons Study Commission. Prevention, Education, and Outreach Subcommittee.
core  

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Beyond borders and blockades: human trafficking risks among vulnerable Palestinian populations under occupation. [PDF]

BMC Public Health
Iyrot I, Noairat R, El Meghary N.
europepmc   +1 more source

Erratum: Reframing human trafficking awareness campaigns in the United States: goals, audience, and content. [PDF]

Front Public Health, 2023
Frontiers Production Office.
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source