Results 81 to 90 of about 8,999,016 (386)

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

open access: yesMolecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo   +6 more
wiley   +1 more source

The measuring and monitoring of human trafficking [PDF]

open access: yesPublic Administration and Policy, 2018
Purpose – The purpose of this paper is to discuss the difficulty of measuring and monitoring of human trafficking within the context of the 2030 Agenda and its Sustainable Development Goals (SDGs).
Raymond Saner, Lichia Yiu, Laurel Rush
doaj   +1 more source

The Rise of Mobile and the Diffusion of Technology-Facilitated Trafficking [PDF]

open access: yes, 2012
In this report, researchers at the USC Annenberg Center on Communication Leadership & Policy (CCLP) reveal how those involved in human trafficking have been quick to adapt to the 21st-century global landscape.
Amber Bissell   +6 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

An analysis of the spatial and temporal variations of human trafficking in India

open access: yesCogent Social Sciences
Human trafficking is one of the most rapidly increasing forms of transnational crime. Globally, an estimated 25 million adults and children are subjected to modern slavery or human trafficking.
Tushar Dakua   +2 more
doaj   +1 more source

Human Trafficking: Fighting the Hidden Crime of Modern-Day Slavery [PDF]

open access: yes, 2014
The issue brief examines the link between economic insecurity in our community's most vulnerable populations and the prevalence of human trafficking.

core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Trafficking in Persons in Latin America and the Caribbean [PDF]

open access: yes, 2008
[Excerpt] Trafficking in persons (TIP) for the purpose of exploitation is a lucrative criminal activity that is of major concern to the United States and the international community. According to the most recent U.S.
Ribando Seelke, Clare
core   +8 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

South Africa – Safe Haven for Human Traffickers? Employing the Arsenal of Existing Law to Combat Human Trafficking

open access: yesPotchefstroom Electronic Law Journal, 2012
Having ratified the Protocol to Prevent, Suppress and Punish Trafficking in Persons, Especially Women and Children, South Africa is obliged to adopt legislative measures that criminalise human trafficking and comply with other standards laid down in this
H Oosthuizen, HB Kruger
doaj  

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