Results 81 to 90 of about 8,155,367 (276)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Help-seeking strategies of victim/survivors of human trafficking involving partner migration [PDF]

open access: yes, 2014
Drawing on research undertaken to explore the role of partner migration in human trafficking into Australia, this paper presents qualitative data on the help-seeking strategies of victim/survivors of human trafficking and similar exploitative situations ...
Samantha Lyneham   +3 more
core  

Trade of women as one of the forms of violence against women [PDF]

open access: yesGlasnik Advokatske komore Vojvodine, 2018
Trafficking is one of the many forms of violence against women. Although other victims may also be victims of trafficking in human beings, women are most often victims.
Tošić Danijela
doaj  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Human Exploitation and Trafficking

open access: yesCrimRxiv
Human exploitation and trafficking are widespread, constantly changing, and hard to detect. This narrative review examines these crimes as forms of coercive benefit extraction. It synthesizes multidisciplinary evidence on exploiter tactics, trafficking modalities, and victim characteristics across regions and sectors. We foreground actual behavior over
openaire   +2 more sources

The Links between Human Trafficking and Wildlife Trafficking

open access: yes
This chapter reviews the convergences that occur between human trafficking and illegal wildlife trade according to information and case studies reported in the literature, including academic and gray publications, as well as the authors’ personal knowledge and empirical research in this area.
Anagnostou, Michelle, van Uhm, Daan
openaire   +2 more sources

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

open access: yesFEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli   +2 more
wiley   +1 more source

Sex trafficking fact sheet

open access: yes, 2023
This fact sheet contains information about sex ...
South Carolina Human Trafficking Task Force
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Psychosocial Factors of Adolescent Survivors of Human Trafficking in East India

open access: yesIndian Journal of Social Psychiatry
Introduction: Human trafficking is referred to as modern-day slavery and is a human rights violation. India is home to 14 million survivors of trafficking, making it one of the most extensive destination grounds for the trafficking of young girls ...
Sheeba Shamsudeen   +3 more
doaj   +1 more source

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