Results 81 to 90 of about 287,942 (280)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Trade of women as one of the forms of violence against women [PDF]

open access: yesGlasnik Advokatske komore Vojvodine, 2018
Trafficking is one of the many forms of violence against women. Although other victims may also be victims of trafficking in human beings, women are most often victims.
Tošić Danijela
doaj  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Help eliminate human trafficking.; Other title: Trafico humano

open access: yes, 2013
Spanish version of: Help eliminate human trafficking.; "Mike DeWine, Ohio Attorney General."; "Created: 4/4/2013 ..."--Document properties screen.; "Protecting Ohio's Families.

core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Psychosocial Factors of Adolescent Survivors of Human Trafficking in East India

open access: yesIndian Journal of Social Psychiatry
Introduction: Human trafficking is referred to as modern-day slavery and is a human rights violation. India is home to 14 million survivors of trafficking, making it one of the most extensive destination grounds for the trafficking of young girls ...
Sheeba Shamsudeen   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Human trafficking and slavery offenders in Australia [PDF]

open access: yes, 2013
This paper provides an assessment of offenders who commit human trafficking, slavery and slave-like crimes in Australia. Foreword: There is a lack of international and Australian research about offenders who have been convicted of human trafficking ...
Frances Simmons
core  

Human trafficking fact sheet

open access: yes, 2023
This fact sheet contains information on human ...
South Carolina Human Trafficking Task Force
core  

Home - About - Disclaimer - Privacy