Results 111 to 120 of about 1,925,938 (268)

Vestibular Migraine: from Differential Diagnosis and Pathophysiology to Treatment Options

Journal of Rehabilitation Sciences and Research, 2018
Background: The occurrence of migraine and vertigo is common in the general population. Migraine vertigo is challenging and has several common symptoms with inner ear pathologies like Endolymphatic Hydropse.
Farzaneh Zamiri Abdollahi, Afsaneh Doost, Maryam Delphi4   +2 more
doaj  

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

DNA Repair Pathway Variants Are Enriched in Individuals with Biallelic AAGGG CANVAS and RFC1‐Related Disease

Movement Disorders, EarlyView.
Abstract Background Cerebellar ataxia, neuropathy and vestibular are flexia syndrome (CANVAS) and RFC1‐related disease are most commonly caused by biallelic AAGGG repeat expansions in RFC1. The high population frequency of this expansion compared to the frequency of CANVAS suggests incomplete penetrance.
Xuemin Wang, Liam G. Fearnley, Kayli C. Davies, Penny Snell, Stuart Lee, Victoria E. Jackson, Justin Read, Michael Milton, Ian H. Harding, Martin B. Delatycki, David J. Szmulewicz, Paul J. Lockhart, Melanie Bahlo, Haloom Rafehi   +13 more
wiley   +1 more source

Why Use Immersive Virtual Reality to Assess Gait in Functional Motor Disorders?

Movement Disorders, EarlyView.
Abstract Background Functional motor disorders (FMD) are disabling conditions modulated by attentional demands. Immersive virtual reality (iVR) engages multiple attentional and sensory networks, but its application in people with FMD (PwFMD) remains limited.
Marialuisa Gandolfi, Chiara Bonetto, Corrado Perin, Angela Sandri, Giulia Bonardi, Ilaria Antonella Di Vico, Laura Avanzino, Elisa Pelosin, Mauro Crestani, Christian Geroin, Denis Vidale, Marco Pirini, Mirta Fiorio, Michele Tinazzi, Francesca Salaorni   +14 more
wiley   +1 more source

A Protocol for Reconstructing Complex Lateral Skull Base Defects: Two Decades of Tertiary Care Experience

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To describe a multidisciplinary protocol for the resection and reconstruction of complex lateral skull base pathology, based on over two decades of experience in a high‐volume tertiary referral center in the United Kingdom. Study Design Retrospective descriptive analysis of institutional practice. Setting A high‐volume tertiary skull
Muhammad Umar Farooq, Yuri Hirayama, Jameel Muzaffar, Raghu Kumar, Charlie Huins, Peter Monksfield, James Baden, Demetrius Evriviades, Richard Irving   +8 more
wiley   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Effect of a virtual walking and therapeutic exercise‐based intervention on gait and balance in people with incomplete spinal cord injury

PM&R, EarlyView.
Abstract Background People with spinal cord injury (SCI) experience sensory and motor impairments that often require exercise‐based treatments. However, these interventions are challenging due to limited active mobility. Novel rehabilitation approaches, such as those targeting the mirror neuron system, could offer additional benefits.
Sara Mollà‐Casanova, Elena Muñoz‐Gómez, Núria Sempere‐Rubio, Noemí Moreno‐Segura, Marta Inglés, Luis‐Millán González, Pilar Serra‐Añó   +6 more
wiley   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Brain‐Inspired Neuromorphic Device for Artificial Intelligent Robots Applications

SmartBot, EarlyView.
Brain‐inspired neuromorphic devices mimic biological systems to provide an efficient hardware foundation for embodied intelligent robotics. This review explores the material systems and corresponding computing architectures of neuromorphic devices that support low‐power perception, adaptive learning, and real‐time decision‐making.
Jiachen Han, Zheng Wang, Tianyu Wang, Jialin Meng   +3 more
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source