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Ten computational challenges in human virome studies. [PDF]

open access: greenVirol Sin
In recent years, substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases. Despite this progress, the field of human virome research remains nascent, primarily hindered by the lack of effective methods, particularly in the domain of computational tools.
Wu Y, Peng Y.
europepmc   +7 more sources

Exploring the Diversity of the Human Blood Virome [PDF]

open access: yesViruses, 2021
Metagenomics is greatly improving our ability to discover new viruses, as well as their possible associations with disease. However, metagenomics has also changed our understanding of viruses in general.
María Cebriá-Mendoza   +6 more
doaj   +14 more sources

Exposing the Human Virome [PDF]

open access: bronzeClinical Chemistry, 2015
As medicine advances, we have come to realize that viral infections early in life can still be playing out in our body decades later, long after the primary infection has ended. New research has indicated that viral infections can precipitate the onset of a diverse array of long-term illnesses, from Alzheimer disease to chronic fatigue syndrome and ...
Vikram Sheel Kumar, Molly Webster
openalex   +4 more sources

The human gut virome: a multifaceted majority [PDF]

open access: yesFrontiers in Microbiology, 2015
Here we outline our current understanding of the human gut virome, in particular the phage component of this ecosystem, highlighting progress and challenges in viral discovery in this arena.
Lesley Ann Ogilvie   +3 more
doaj   +3 more sources

Virome genomics: a tool for defining the human virome

open access: hybridCurrent Opinion in Microbiology, 2013
High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host that control infections, and ...
Kristine M. Wylie   +2 more
openalex   +4 more sources

Role of the Virome in Vaccine-Induced Immunization [PDF]

open access: yesVaccines
The human virome—comprising viruses that can persist in a host, those that benefit the host, and those that remain latent—has gained increasing acceptance as a modulator of immune response toward vaccination.
Rossella Cianci   +6 more
doaj   +2 more sources

Emerging view of the human virome [PDF]

open access: hybridTranslational Research, 2012
The human virome is the collection of all viruses that are found in or on humans, including both eukaryotic and prokaryotic viruses. Eukaryotic viruses clearly have important effects on human health, ranging from mild, self-limited acute or chronic infections to those with serious or fatal consequences.
Kristine M. Wylie   +2 more
openalex   +4 more sources

Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients [PDF]

open access: yesFrontiers in Cellular and Infection Microbiology
BackgroundMetagenomic next-generation sequencing (mNGS) enables comprehensive profiling of viral communities in clinical samples. However, comparative analyses of the virome across anatomical compartments and disease states remain limited.
Ning Zheng   +10 more
doaj   +2 more sources

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