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The review is dealt with virome, a viral component of human microbiome. Modern data are discussed that concern the structure of virome, its formation during ontogenesis, the role in disease pathogeneses and in homeostasis maintenance. Special attention is payed to bacteriophages (phagobiome) as dominant members of virome.
D.S. Yankovsky +4 more
openaire +2 more sources
Virome Sequencing of the Human Intestinal Mucosal–Luminal Interface
While the human gut virome has been increasingly explored in recent years, nearly all studies have been limited to fecal sampling. The mucosal–luminal interface has been established as a viable sample type for profiling the microbial biogeography of the ...
Austin Yan +4 more
doaj +1 more source
Does the Human Gut Virome Contribute to Host Health or Disease?
The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the “gut virome”.
Grazia Pavia +3 more
doaj +1 more source
Multiomic spatial analysis reveals a distinct mucosa-associated virome
The human gut virome has been increasingly explored in recent years. However, nearly all virome-sequencing efforts rely solely on fecal samples and few studies leverage multiomic approaches to investigate phage–host relationships.
Austin Yan +4 more
doaj +1 more source
The human virome: new tools and concepts [PDF]
The human virome is the viral component of the microbiome. Its composition, and interindividual and temporal variability are not precisely known. Its impact on human health has received less attention than that of the bacterial microbiome, but is likely to be equally important, both in homeostasis and disease. Here we review the recent advances in this
Marc Eloit, Marc Eloit, Marc Lecuit
openaire +4 more sources
Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases
More recently, increasing attention has been directed to exploring the function of the global virome in health and disease. Currently, by new molecular techniques, such as metagenomic DNA sequencing, the virome has been better unveiled.
Giulia Dodi +4 more
doaj +1 more source
Deciphering the Human Virome with Single-Virus Genomics and Metagenomics. [PDF]
Single-cell genomics has unveiled the metabolic potential of dominant microbes inhabiting different environments, including the human body. The lack of genomic information for predominant microbes of the human body, such as bacteriophages, hinders our ability to answer fundamental questions about our viral communities.
de la Cruz Peña MJ +5 more
europepmc +8 more sources
Sensitive detection systems for infectious agents in xenotransplantation*
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
The Human Gut Virome in Hypertension
Objectives: Previous studies have reported that the gut microbiome has an important link with the development of hypertension. Though previous researches have focused on the links of gut bacteria with hypertension, little has been known about the linkage of gut viruses to hypertension and the development of hypertension, largely due to the lack of data
Kang Ning +4 more
openaire +4 more sources
Rapid evolution of the human gut virome [PDF]
Humans are colonized by immense populations of viruses, which metagenomic analysis shows are mostly unique to each individual. To investigate the origin and evolution of the human gut virome, we analyzed the viral community of one adult individual over 2.5 y by extremely deep metagenomic sequencing (56 billion bases of purified viral ...
Christel Chehoud +5 more
openaire +2 more sources

