Results 41 to 50 of about 8,694 (213)

Prediction of the receptorome for the human-infecting virome [PDF]

Virologica Sinica, 2020
AbstractThe virus receptors are key for the viral infection of host cells. Identification of the virus receptors is still challenging at present. Our previous study has shown that human virus receptor proteins have some unique features including high N-glycosylation level, high number of interaction partners and high expression level.
Zheng Zhang, Sifan Ye, Aiping Wu, Taijiao Jiang, Yousong Peng   +4 more
openaire   +2 more sources

Rapid evolution of the human gut virome [PDF]

Proceedings of the National Academy of Sciences, 2013
Humans are colonized by immense populations of viruses, which metagenomic analysis shows are mostly unique to each individual. To investigate the origin and evolution of the human gut virome, we analyzed the viral community of one adult individual over 2.5 y by extremely deep metagenomic sequencing (56 billion bases of purified viral ...
Samuel, Minot, Alexandra, Bryson, Christel, Chehoud, Gary D, Wu, James D, Lewis, Frederic D, Bushman   +5 more
openaire   +2 more sources

Challenges of Studying the Human Virome – Relevant Emerging Technologies [PDF]

Trends in Microbiology, 2021
In this review we provide an overview of current challenges and advances in bacteriophage research within the growing field of viromics. In particular, we discuss, from a human virome study perspective, the current and emerging technologies available, their limitations in terms of de novo discoveries, and possible solutions to overcome present ...
Khan Mirzaei, Mohammadali, Xue, Jinling, Costa, Rita, Ru, Jinlong, Schulz, Sarah, Taranu, Zofia E., Deng, Li   +6 more
openaire   +4 more sources

Hypervariable loci in the human gut virome [PDF]

Proceedings of the National Academy of Sciences, 2012
Genetic variation is critical in microbial immune evasion and drug resistance, but variation has rarely been studied in complex heterogeneous communities such as the human microbiome. To begin to study natural variation, we analyzed DNA viruses present in the lower gastrointestinal tract of 12 human volunteers by determining 48 billion bases of viral ...
Samuel, Minot, Stephanie, Grunberg, Gary D, Wu, James D, Lewis, Frederic D, Bushman   +4 more
openaire   +2 more sources

Formation of Genetically Determined Resistance against Human Norovirus Infection through Polymorphism of the FUT2 gene: a Review of the Literature

Эпидемиология и вакцинопрофилактика
Relevance. Human Noroviruses (HuNoV) are highly contagious pathogens responsible of acute human norovirus infection. HuNoV is the cause of every fifth case of acute non-bacterial gastroenteritis, annually causing about 699 million cases of the disease ...
R. O. Bykov, A. V. Semenov, P. K. Starikova, T. M. Itani   +3 more
doaj   +1 more source

Human Virome and Disease: High-Throughput Sequencing for Virus Discovery, Identification of Phage-Bacteria Dysbiosis and Development of Therapeutic Approaches with Emphasis on the Human Gut

Viruses, 2019
The virome is comprised of endogenous retroviruses, eukaryotic viruses, and bacteriophages and is increasingly being recognized as an essential part of the human microbiome. The human virome is associated with Type-1 diabetes (T1D), Type-2 diabetes (T2D),
Tasha M. Santiago-Rodriguez, Emily B. Hollister   +1 more
doaj   +1 more source

Genetic Diversity of the Non-Polio Enteroviruses Detected in Samples of Patients with Aseptic Meningitis in the Ural Federal District and Western Siberia

Viruses
Human non-polio enteroviruses (NPEVs) cause a plethora of infections in humans, ranging from mild to severe neurological diseases including aseptic meningitis. NPEVs are the leading cause of aseptic meningitis in both children and adults worldwide.
Tarek M. Itani, Vladislav I. Chalapa, Anastasia K. Patrusheva, Evgeniy S. Kuznetsov, Aleksandr V. Semenov   +4 more
doaj   +1 more source

The human virome: new tools and concepts [PDF]

Trends in Microbiology, 2013
The human virome is the viral component of the microbiome. Its composition, and interindividual and temporal variability are not precisely known. Its impact on human health has received less attention than that of the bacterial microbiome, but is likely to be equally important, both in homeostasis and disease. Here we review the recent advances in this
Lecuit, Marc, Eloit, Marc
openaire   +3 more sources

Analysis of Population Immunity to Tick-Borne Encephalitis Virus in the Sverdlovsk Region

Эпидемиология и вакцинопрофилактика
Relevance. The study of population immunity to the tick-borne encephalitis virus in endemic areas helps to identify the circulation of the virus, makes it possible to assess the dynamics of the activity of natural foci and determine the area of ...
V. A. Mishchenko, I. P. Bykov, N. G. Popkova, A. M. Orlov, I. V. Vyalykh   +4 more
doaj   +1 more source

Comparison of PCR versus PCR-Free DNA Library Preparation for Characterising the Human Faecal Virome

Viruses, 2021
The human intestinal microbiota is abundant in viruses, comprising mainly bacteriophages, occasionally outnumbering bacteria 10:1 and is termed the virome.
Shen-Yuan Hsieh, Mohammad A. Tariq, Andrea Telatin, Rebecca Ansorge, Evelien M. Adriaenssens, George M. Savva, Catherine Booth, Tom Wileman, Lesley Hoyles, Simon R. Carding   +9 more
doaj   +1 more source