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Comparison of PCR versus PCR-Free DNA Library Preparation for Characterising the Human Faecal Virome
The human intestinal microbiota is abundant in viruses, comprising mainly bacteriophages, occasionally outnumbering bacteria 10:1 and is termed the virome.
Shen-Yuan Hsieh +9 more
doaj +1 more source
Relevance. Human Noroviruses (HuNoV) are highly contagious pathogens responsible of acute human norovirus infection. HuNoV is the cause of every fifth case of acute non-bacterial gastroenteritis, annually causing about 699 million cases of the disease ...
R. O. Bykov +3 more
doaj +1 more source
Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome?
The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses.
Alfredo Focà +5 more
doaj +1 more source
The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution. [PDF]
Wang X +25 more
europepmc +2 more sources
Analysis of Population Immunity to Tick-Borne Encephalitis Virus in the Sverdlovsk Region
Relevance. The study of population immunity to the tick-borne encephalitis virus in endemic areas helps to identify the circulation of the virus, makes it possible to assess the dynamics of the activity of natural foci and determine the area of ...
V. A. Mishchenko +4 more
doaj +1 more source
The human gut virome: form and function [PDF]
Advances in next-generation sequencing technologies and the application of metagenomic approaches have fuelled an exponential increase in our understanding of the human gut microbiome. These approaches are now also illuminating features of the diverse and abundant collection of viruses (termed the virome) subsisting with the microbial ecosystems ...
Ogilvie, Lesley, Jones, Brian
openaire +3 more sources
Low-cost DNA sequencing has greatly democratized genomics, especially for the typically very small genomes of viruses [1]–[3]. The recent acceleration in human virus discovery by metagenomics indicates that many viruses escaped prior detection due to limitations of preexisting technologies.
openaire +5 more sources
Human noroviruses (HuNoVs) are highly contagious pathogens responsible of norovirus-associated acute gastroenteritis (AGE). GII.4 is the prevailing HuNoV genotype worldwide.
Roman Bykov +7 more
doaj +1 more source
Hypervariable loci in the human gut virome [PDF]
Genetic variation is critical in microbial immune evasion and drug resistance, but variation has rarely been studied in complex heterogeneous communities such as the human microbiome. To begin to study natural variation, we analyzed DNA viruses present in the lower gastrointestinal tract of 12 human volunteers by determining 48 billion bases of viral ...
Gary D. Wu +4 more
openaire +3 more sources
The gut virome: the ‘missing link’ between gut bacteria and host immunity?
The human gut virome includes a diverse collection of viruses that infect our own cells as well as other commensal organisms, directly impacting on our well-being. Despite its predominance, the virome remains one of the least understood components of the
Indrani Mukhopadhya +4 more
doaj +1 more source

