Results 61 to 70 of about 8,242 (199)

Choice of assembly software has a critical impact on virome characterisation

Microbiome, 2019
Background The viral component of microbial communities plays a vital role in driving bacterial diversity, facilitating nutrient turnover and shaping community composition.
Thomas D. S. Sutton, Adam G. Clooney, Feargal J. Ryan, R. Paul Ross, Colin Hill   +4 more
doaj   +1 more source

Varidnaviruses in the Human Gut: A Major Expansion of the Order Vinavirales

Viruses, 2022
Bacteriophages play key roles in the dynamics of the human microbiome. By far the most abundant components of the human gut virome are tailed bacteriophages of the realm Duplodnaviria, in particular, crAss-like phages. However, apart from duplodnaviruses,
Natalya Yutin, Mike Rayko, Dmitry Antipov, Pascal Mutz, Yuri I. Wolf, Mart Krupovic, Eugene V. Koonin   +6 more
doaj   +1 more source

The Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut [PDF]

Cell Host & Microbe, 2020
The gut microbiome profoundly affects human health and disease, and their infecting viruses are likely as important, but often missed because of reference database limitations. Here, we (1) built a human Gut Virome Database (GVD) from 2,697 viral particle or microbial metagenomes from 1,986 individuals representing 16 countries, (2) assess its ...
Gregory, Ann C., Zablocki, Olivier, Zayed, Ahmed A., Howell, Allison, Bolduc, Benjamin, Sullivan, Matthew B.   +5 more
openaire   +2 more sources

CLAE: A High‐Fidelity Nanopore Sequencing Strategy for Read‐Level Viral Variant Detection and Environmental RNA Virus Discovery

Advanced Science, EarlyView.
High‐fidelity Nanopore sequencing offers a cost‐effective, portable path to uncovering viral dark matter in complex environments—but suffers from severe read‐length bias, low throughput, and limited accuracy. This study traces these limitations to core biochemical barriers and introduces CLAE, a foundational high‐fidelity platform that enables accurate,
Hannah Yu, Sarah Golconda, Ga‐Eun Lee, Dantong Xue, Guillermo Domínguez‐Huerta, James M. Wainaina, Benjamin Bolduc, Shashanka Murthy, Shihyoung Kim, Seth Faith, Shan‐Lu Liu, Jiyoung Lee, Michael Oglesbee, Matthew B Sullivan, Sanggu Kim   +14 more
wiley   +1 more source

Plasma virome dynamics in chronic hepatitis B virus infected patients

Frontiers in Microbiology, 2023
The virome remains an understudied domain of the human microbiome. The role of commensal viruses on the outcome of infections with known pathogens is not well characterized.
Marijn Thijssen, Frank Tacke, Lore Van Espen, David Cassiman, Mahmoud Naser Aldine, Frederik Nevens, Marc Van Ranst, Jelle Matthijnssens, Mahmoud Reza Pourkarim, Mahmoud Reza Pourkarim, Mahmoud Reza Pourkarim   +10 more
doaj   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

Molecular Characterization and Epidemiology of Human Noroviruses in the Sverdlovsk Region, Russian Federation

Viruses
Human noroviruses (HuNoVs) stand as the primary cause of acute viral gastroenteritis outbreaks worldwide, particularly impacting children under the age of five.
Roman Bykov, Tarek Itani, Daria Pletenchuk, Olesia Ohlopkova, Alexey Moshkin, Marina Stepanyuk, Aleksandr Semenov   +6 more
doaj   +1 more source

A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog

mSystems, 2021
Gut viruses are important, yet often neglected, players in the complex human gut microbial ecosystem. Recently, the number of human gut virome studies has been increasing; however, we are still only scratching the surface of the immense viral diversity ...
Lore Van Espen, Emilie Glad Bak, Leen Beller, Lila Close, Ward Deboutte, Helene Bæk Juel, Trine Nielsen, Deniz Sinar, Lander De Coninck, Christine Frithioff-Bøjsøe, Cilius Esmann Fonvig, Suganya Jacobsen, Maria Kjærgaard, Maja Thiele, Anthony Fullam, Michael Kuhn, Jens-Christian Holm, Peer Bork, Aleksander Krag, Torben Hansen, Manimozhiyan Arumugam, Jelle Matthijnssens   +21 more
doaj   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, EarlyView.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

Analysis of the overall development trends and hotspots in the research field of the human gut virome. [PDF]

Virol J
Zhang Y, Mei T, Wang M, Huang C, Yi H, Zhan Y, Yang S, Wang H, Yan Q, Guo R, Chen C.   +10 more
europepmc   +2 more sources